Cefepime sulfate

Base Information

• Chemical Name: Cefepime sulfate
• CAS No.: 107648-78-2
• Molecular Formula: C₁₉H₂₄N₆O₅S₂*H₂O₄S
• Molecular Weight: 578.648
• UNII: YP33Y0FYAE
• Mol file: 107648-78-2.mol

Synonyms:Cefepime sulfate;Cefepime sulphate;107648-78-2;UNII-YP33Y0FYAE;YP33Y0FYAE;(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;sulfuric acid;Pyrrolidinium, 1-(((6R,7R)-7-(((2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methyl-, sulfate (1:1);SCHEMBL4471755

Chemical Property of Cefepime sulfate

Chemical Property:

• Appearance/Colour: White powder
• PSA: 286.56000
• LogP: 1.00900
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 6
• Exact Mass: 578.09233995
• Heavy Atom Count: 37
• Complexity: 950

Purity/Quality:

99% ^*data from raw suppliers

CEFEPIME SULFATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[N+]1(CCCC1)CC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-].OS(=O)(=O)O
• Isomeric SMILES: C[N+]1(CCCC1)CC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-].OS(=O)(=O)O

Technology Process of Cefepime sulfate

There total 5 articles about Cefepime sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(2-Amino-thiazol-4-yl)-[(Z)-methoxyimino]-thioacetic acid S-(5-methyl-[1,3,4]thiadiazol-2-yl) ester (131990-96-0) + C13H19N3O3S*HI (111390-01-3) → cefepime sulfate (107648-78-2,112710-02-8,149261-28-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; for 0.5h; pH 6.5;

DOI:10.1016/S0040-4039(00)97096-5

Reference yield: 72.0%

1-(2-Amino-thiazol-4-yl)-2-(4-methyl-5-thioxo-4,5-dihydro-tetrazol-1-yl)-ethane-1,2-dione 1-(O-methyl-oxime) (131990-94-8) + C13H19N3O3S*HI (111390-01-3) → cefepime sulfate (107648-78-2,112710-02-8,149261-28-9)

Guidance literature:

With sodium hydroxide; In water; acetone; for 0.5h; pH 6.5;

DOI:10.1016/S0040-4039(00)97096-5

Reference yield: 66.0%

1-(2-Amino-thiazol-4-yl)-2-(4-methyl-5-thioxo-4,5-dihydro-tetrazol-1-yl)-ethane-1,2-dione 1-(O-methyl-oxime) (131990-94-8) + 1-[(7-amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl]-1-methyl-pyrrolidinium-chloride (103121-85-3) → cefepime sulfate (107648-78-2,112710-02-8,149261-28-9)

Guidance literature:

With sodium hydroxide; In water; N,N-dimethyl-formamide; for 0.5h; pH 6.5;

DOI:10.1016/S0040-4039(00)97096-5

upstream raw materials:

1-(2-Amino-thiazol-4-yl)-2-(5-methyl-2-thioxo-[1,3,4]thiadiazol-3-yl)-ethane-1,2-dione 1-(O-methyl-oxime)

C₁₃H₁₉N₃O₃S*HI

(2-Amino-thiazol-4-yl)-[(Z)-methoxyimino]-thioacetic acid S-(5-methyl-[1,3,4]thiadiazol-2-yl) ester

1-(2-Amino-thiazol-4-yl)-2-(4-methyl-5-thioxo-4,5-dihydro-tetrazol-1-yl)-ethane-1,2-dione 1-(O-methyl-oxime)

Refernces