METHYL 2-HYDROXYOCTADECANOATE

Base Information

• Chemical Name: METHYL 2-HYDROXYOCTADECANOATE
• CAS No.: 2420-35-1
• Molecular Formula: C19H38 O3
• Molecular Weight: 314.509
• Hs Code.: 2918199090
• Mol file: 2420-35-1.mol

Synonyms:(?à)-Methyl 2-Hydroxyoctadecanoate;Methyl 2-hydroxyoctadecanoate; Methyl 2-hydroxystearate; MethylDL-2-hydroxyoctadecanoate

Chemical Property of METHYL 2-HYDROXYOCTADECANOATE

Chemical Property:

• Melting Point: 64-66 °C
• Boiling Point: 354.8±10.0 °C(Predicted)
• PKA: 13.03±0.20(Predicted)
• Flash Point: 160.5oC
• PSA: 46.53000
• Density: 0.915±0.06 g/cm3(Predicted)
• LogP: 5.39170
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

2-hydroxy Stearic Acid methyl ester ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: 2-hydroxy Stearic acid is a hydroxylated fatty acid methyl ester that broadens phase transition in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugate anti-HIV agents to increase phosphodiester bond cleavage and the amount of liberated intracellular nucleotides. [Matreya, LLC. Catalog No. 1708]

Technology Process of METHYL 2-HYDROXYOCTADECANOATE

There total 11 articles about METHYL 2-HYDROXYOCTADECANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (4E,8E,10E)-1-(β-D-glucopyranosyloxy)-3-hydroxy-2-[2-hydroxyoctadecanoyl]amino-9-methyl-4,8,10-octadecatriene → methyl D-glucopyranoside (97-30-3,617-04-9,709-50-2,1824-94-8,2152-78-5,3396-99-4,6819-48-3,18469-06-2,20550-04-3,22277-65-2,29411-57-2,35437-40-2,35437-43-5,36191-11-4,36191-12-5,39598-79-3,39598-80-6,39598-89-5,51023-63-3,51223-62-2,51224-38-5,51224-39-6,51224-40-9,51224-41-0,51819-81-9,51819-82-0,51819-83-1,56688-81-4,62279-53-2,64281-79-4,64281-80-7,64912-19-2,66101-73-3,78184-90-4,84368-39-8,84368-40-1,84368-41-2,92142-37-5,93302-26-2,103421-28-9,115794-08-6,3149-68-6) + 2-hydroxyoctadecanoic acid methyl ester (2420-35-1,40617-55-8) + 2-amino-9-methyl-4,8,10-octadecatriene-1,3-diol

Guidance literature:

With hydrogenchloride; at 70 ℃;

DOI:10.1002/rcm.4896

Reference yield:

methanol (67-56-1) + (2S,3S,4R,10E)-2-{[(2R)-2-hydroxyoctdecanoy]amino}tricont-10-ene-1,3,4-triol → 2-hydroxyoctadecanoic acid methyl ester (2420-35-1,40617-55-8) + C32H63NO4

Guidance literature:

With hydrogenchloride; In water; for 15h; Reflux;

DOI:10.1080/10286020.2013.812643

Reference yield:

methanol (67-56-1) + (2S,3S,4R)-2-{[(2R)-2-hydroxyoctdecanoy]amino}hexaeicosane-1,3,4-triol (1588950-14-4) → 2-hydroxyoctadecanoic acid methyl ester (2420-35-1,40617-55-8) + C28H57NO4

Guidance literature:

With hydrogenchloride; In water; for 15h; Reflux;

DOI:10.1080/10286020.2013.812643

upstream raw materials:

diazomethane

2-hydroxystearic acid

methanol

Methyl 2-bromostearate

Downstream raw materials:

C₂₆H₃₇F₅O₄

heptadecanoic acid

2-hydroxystearic acid

Refernces

• 1、 Riaz, Naheed,Tabussum, Asia,Saleem, Muhammad,Ashraf, Muhammad,Nasar, Romana,Jabeen, Bushra,Malik, Abdul,Jabbar, Abdul. "New lipoxygenase inhibitory sphingolipids from Chrozophora plicata". . p. 1080 - 1087. Retrieved 2014/01/06.
• 2、 Ahn, Young Min,Lee, Won-Woong,Jung, Jee H.,Lee, Sang-Gi,Honga, Jongki. "Structural determination of glucosylceramides isolated from marine sponge by fast atom bombardment collision-induced dissociation linked scan at constant B/E". experimental part. p. 1698 - 1708. Retrieved 2010/07/05.