SULFAMETHAZINE

Base Information

• Chemical Name: SULFAMETHAZINE
• CAS No.: 35762-76-6
• Molecular Formula: C6H9 N3 O2 S
• Molecular Weight: 187.222
• Hs Code.: 2935002000
• Mol file: 35762-76-6.mol

Synonyms:4,6-Dimethylpyrimidine-2-sulfonamide

Chemical Property of SULFAMETHAZINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 197-200 °C
• Refractive Index: 1.554
• Boiling Point: 420.4°Cat760mmHg
• PKA: 8.51±0.60(Predicted)
• Flash Point: 208°C
• PSA: 94.32000
• Density: 1.362g/cm³
• LogP: 1.52190
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4,6-dimethylpyrimidine-2-sulfonamide 95% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of SULFAMETHAZINE

There total 4 articles about SULFAMETHAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.6%

4,6-dimethyl-2-meraptopyrimidine (22325-27-5,131321-42-1) → 4,6-dimethyl-pyrimidine-2-sulfonic acid amide (35762-76-6)

Guidance literature:

4,6-dimethyl-2-meraptopyrimidine; With hydrogenchloride; sodium hypochlorite; calcium chloride; In dichloromethane; water; at -23 ℃; for 0.25h;

With ammonia; In dichloromethane; at -70 - 20 ℃; for 16.25h;

Reference yield:

4,6-dimethyl-pyrimidine-2-sulfonyl chloride (69812-31-3) → 4,6-dimethyl-pyrimidine-2-sulfonic acid amide (35762-76-6)

Guidance literature:

With ammonia;

DOI:10.1021/ja01167a011

Reference yield:

4,6-dimethyl-pyrimidine-2-thione (22325-27-5) → 4,6-dimethyl-pyrimidine-2-sulfonic acid amide (35762-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl; chlorine; water

2: NH₃

With hydrogenchloride; ammonia; water; chlorine;

DOI:10.1021/ja01167a011

upstream raw materials:

4,6-dimethyl-pyrimidine-2-sulfonyl chloride

4,6-dimethyl-pyrimidine-2-thione

4,6-dimethyl-2-meraptopyrimidine

Refernces

• 1、 Brown,Hoskins. "Simple pyrimidines. XIV. The formation and reactions of some derivatives of simple pyrimidinesulphonic acids.". . p. 522 - 527. Retrieved 2007/10/04.