Technology Process of N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]-18,18,18-d3-octadecanamid
There total 15 articles about N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]-18,18,18-d3-octadecanamid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
18,18,18-d3-octadecanoic acid;
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
for 0.25h;
(2S,3R,4E)-2-amino-4-octadecene-1,3-diol;
In
dichloromethane;
for 12h;
DOI:10.1002/jlcr.3443
- Guidance literature:
-
deuterated octadecanoic acid;
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
for 0.25h;
(2S,3R,4E)-2-amino-4-octadecene-1,3-diol;
In
dichloromethane;
for 12h;
DOI:10.1002/jlcr.3443
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium aluminium tetrahydride / diethyl ether / Reflux
2.1: triethylamine / chloroform / 14 h / 0 - 20 °C
3.1: lithium bromide / acetone / 6 h / Reflux
4.1: magnesium / tetrahydrofuran / 3 h / 50 °C / Inert atmosphere
4.2: 3 h / -10 - -5 °C / Inert atmosphere
5.1: pyridinium p-toluenesulfonate / methanol / 3 h / Reflux
6.1: sulfuric acid; chromium(VI) oxide / chloroform; acetone / 3 h / 0 °C
7.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h
7.2: 12 h
With
chromium(VI) oxide; lithium aluminium tetrahydride; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; pyridinium p-toluenesulfonate; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; lithium bromide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; acetone;
4.1: |Grignard Reaction / 4.2: |Grignard Reaction;
DOI:10.1002/jlcr.3443
