Celaphal A

Base Information

• Chemical Name: Celaphal A
• CAS No.: 244204-40-8
• Molecular Formula: C₁₇H₂₀O₄
• Molecular Weight: 288.343
• Mol file: 244204-40-8.mol

Synonyms:(+)-CelaphanolA; Celaphanol A

Chemical Property of Celaphal A

Chemical Property:

• Boiling Point: 532.9±50.0 °C(Predicted)
• PKA: 7.60±0.60(Predicted)
• PSA: 77.76000
• Density: 1.34±0.1 g/cm3(Predicted)
• LogP: 3.57400

Purity/Quality:

98%min ^*data from raw suppliers

CelaphanolA 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Celaphal A

There total 7 articles about Celaphal A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(+/-)-2,3,4,4a-tetrahydro-10-hydroxy-6,7-dimethoxy-1,1,4a-trimethyl-9(1H)-phenanthrenone (477217-39-3) → (+/-)-celaphanol A (244204-40-8)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1002/jccs.200200089

Reference yield:

α-cyclocitral (14505-74-9,41721-03-3,59462-59-8,432-24-6) → (+/-)-celaphanol A (244204-40-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 79 percent / diethyl ether / 2 h / Heating

2: 85 percent / pyridinium chlorochromate / CH₂Cl₂ / 2.5 h / 20 °C

3: 93 percent / BF₃*Et₂O / CH₂Cl₂ / 24 h / 20 °C

4: 90 percent / CrO₃; acetic acid / 0.5 h / 20 °C

5: 80 percent / t-BuOK / 2-methyl-propan-2-ol / 2 h / 20 °C

6: 85 percent / BBr₃ / CH₂Cl₂ / 0.5 h / 0 °C

With chromium(VI) oxide; boron trifluoride diethyl etherate; potassium tert-butylate; boron tribromide; acetic acid; pyridinium chlorochromate; In diethyl ether; dichloromethane; tert-butyl alcohol;

DOI:10.1002/jccs.200200089

Reference yield:

3,4-dimethoxyphenylmethylmagnesium chloride (108071-30-3) → (+/-)-celaphanol A (244204-40-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 79 percent / diethyl ether / 2 h / Heating

2: 85 percent / pyridinium chlorochromate / CH₂Cl₂ / 2.5 h / 20 °C

3: 93 percent / BF₃*Et₂O / CH₂Cl₂ / 24 h / 20 °C

4: 90 percent / CrO₃; acetic acid / 0.5 h / 20 °C

5: 80 percent / t-BuOK / 2-methyl-propan-2-ol / 2 h / 20 °C

6: 85 percent / BBr₃ / CH₂Cl₂ / 0.5 h / 0 °C

With chromium(VI) oxide; boron trifluoride diethyl etherate; potassium tert-butylate; boron tribromide; acetic acid; pyridinium chlorochromate; In diethyl ether; dichloromethane; tert-butyl alcohol;

DOI:10.1002/jccs.200200089

upstream raw materials:

(+/-)-2,3,4,4a-tetrahydro-10-hydroxy-6,7-dimethoxy-1,1,4a-trimethyl-9(1H)-phenanthrenone

α-cyclocitral

3,4-dimethoxyphenylmethylmagnesium chloride

(cis)-1,2,3,4,4a,10a-hexahydro-6,7-dimethoxy-1,1,4a-trimethyl-9,10-phenanthrenedione

Refernces