ErythrolosaMine

Base Information

• Chemical Name: ErythrolosaMine
• CAS No.: 53066-32-3
• Molecular Formula: C₂₉H₅₃NO₁₀
• Molecular Weight: 575.741
• Mol file: 53066-32-3.mol

Synonyms:

Chemical Property of ErythrolosaMine

Chemical Property:

• Melting Point: 180-189°C
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)

Purity/Quality:

Erythrolosamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Erythrolosamine is a derivative of Erythromycin A Oxime (E650010), which displays no antibacterial activity. It is a potent precursor of ketolide antibiotics.

Technology Process of ErythrolosaMine

There total 2 articles about ErythrolosaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

erythromycin A (114-07-8,86832-48-6,150577-53-0) → (2S,3S,4R)-4-Methoxy-2,4-dimethyl-tetrahydro-pyran-3-ol + (3S,4R,5R,6S,7S,9S,11S,12S,13R,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-4,7,12,13-tetrahydroxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione (53066-32-3)

Guidance literature:

With hydrogenchloride; In acetonitrile; at 37 ℃; Mechanism; decomposition rate constants and half lives at var. pH;

DOI:10.1248/cpb.40.725

Reference yield:

→ 5-O-Desosaminyl-erythronolid A (53066-32-3)

Guidance literature:

Oxim 2, NaNO2;

DOI:10.1021/jm00255a009

upstream raw materials:

erythromycin A

Refernces