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CAS No.: | 57-56-7 |
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Name: | Semicarbazide |
Article Data: | 110 |
Molecular Structure: | |
Formula: | CH5 N3 O |
Molecular Weight: | 75.0702 |
Synonyms: | Isosemicarbazide(8CI); Aminourea; Carbamic acid, hydrazide; Carbamylhydrazine; Carbazamide;Carbazimidic acid; Hydrazine, (aminocarbonyl)-; Semicarbazide; Urea, amino- |
EINECS: | 200-339-6 |
Density: | 1.286±0.06 g/cm3(Predicted) |
Melting Point: | 175-185oC /decomposes/ |
Boiling Point: | 133.71°C (rough estimate) |
Hazard Symbols: | Xn |
Risk Codes: | 22 |
Safety: | A poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by intravenous route: convulsions. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also HYDRAZINE. |
PSA: | 81.14000 |
LogP: | 0.31990 |
Chemistry informtion about Semicarbazide (57-56-7) is:
IUPAC Name: Aminourea
Synonyms: Aminomocovina ; Amino-Ure ; Carbamic Acid, Hydrazide ; Carbamicacid,Hydrazide ; Carbamoyl-Hydrazin ; Carbamylhydrazine ; Carbazamide ; Hydrazine, Carbamoyl-
MF: CH5N3O
MW: 75.07
EINECS: 200-339-6
Density: 1.286 g/cm3
Flash Point: 66.5 °C
Boiling Point: 186.3 °C at 760 mmHg
Vapour Pressure: 0.187 mmHg at 25°C
Enthalpy of Vaporization: 49.18 kJ/mol
Following is the molecular structure of Semicarbazide (57-56-7) is:
Semicarbazide (57-56-7) is used as a detection reagent on thin layer chromatography (TLC). It stains α-keto acids on the TLC plate, which must then be viewed under a UV light to see the results.
Raw materials: Urea → Hydrazine Sulfate → Sodium Cyanate → Semicarbazide Hydrochloride
Preparation Products: Hydrocortisone → 4'-Methylacetophenone → Semicarbazide Hydrochloride → Civetone → 2,6-Dihydroxypurine → Nitrofurantoin → Menthone → 3-Methylcyclopentadecanone → Mitoguazone → 4-Phenylurazole → Acetone Semicarbazone
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | intravenous | 40mg/kg (40mg/kg) | Behavioral: convulsions or effect on seizure threshold | Journal of Pharmacology and Experimental Therapeutics. Vol. 122, Pg. 110, 1958. |
mouse | LD50 | intraperitoneal | 123mg/kg (123mg/kg) | Behavioral: convulsions or effect on seizure threshold | Journal of Pharmacology and Experimental Therapeutics. Vol. 122, Pg. 110, 1958. |
mouse | LD50 | intravenous | 126mg/kg (126mg/kg) | Behavioral: convulsions or effect on seizure threshold | Journal of Pharmacology and Experimental Therapeutics. Vol. 122, Pg. 110, 1958. |
mouse | LD50 | oral | 176mg/kg (176mg/kg) | Behavioral: convulsions or effect on seizure threshold | Journal of Pharmacology and Experimental Therapeutics. Vol. 122, Pg. 110, 1958. |
mouse | LD50 | subcutaneous | 105mg/kg (105mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 119, Pg. 444, 1957. | |
rat | LD50 | intraperitoneal | 140mg/kg (140mg/kg) | Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. Vol. 257, Pg. 296, 1967. | |
rat | LD50 | subcutaneous | 140mg/kg (140mg/kg) |
Reported in EPA TSCA Inventory.
A poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by intravenous route: convulsions. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also HYDRAZINE.
Hazard Codes:
Xn: Harmful
Risk Statements:
R22: Harmful if swallowed.
Safety Statements:
S22: Do not breathe dust.
WGK Germany: 3