104010-37-9 Usage
Description
Ceftiofur sodium is a semi-synthetic, broad-spectrum antibiotic derived from cephalosporin, characterized by its white or light yellow crystalline powder form. It is known for its resistance to the antibiotic resistance enzyme beta-lactamase and exhibits activity against both Gram-positive and Gram-negative bacteria. The bactericidal activity of ceftiofur sodium is attributed to its ability to inhibit cell wall synthesis through its affinity for penicillin-binding proteins (PBPs), which are essential in peptidoglycan biosynthesis. This inhibition prevents the proper synthesis of the vital cell wall component, ultimately leading to bacterial cell death.
Uses
Used in Veterinary Medicine:
Ceftiofur sodium is used as an antibiotic for the treatment of swine bacterial respiratory infections. It is particularly effective in combating such infections due to its broad-spectrum activity and resistance to beta-lactamase, an enzyme that can render certain antibiotics ineffective.
Used in Antibacterial Applications (Veterinary):
Ceftiofur sodium serves as an antibacterial agent in the veterinary industry, where it is utilized to treat various bacterial infections in animals. Its effectiveness against a wide range of bacteria, including both Gram-positive and Gram-negative types, makes it a valuable asset in veterinary medicine.
Used in Combating Antibiotic Resistance:
Due to its resistance to the beta-lactamase enzyme, ceftiofur sodium is used to counteract the growing issue of antibiotic resistance in bacteria. This resistance can render certain antibiotics less effective or even completely ineffective, making the treatment of bacterial infections more challenging. Ceftiofur sodium's ability to withstand beta-lactamase-mediated resistance makes it a crucial tool in the fight against antibiotic resistance.
Brand Name in US:
In the United States, ceftiofur sodium is marketed under the brand name Naxcel, which is specifically formulated for use in veterinary medicine to treat bacterial infections in animals.
Third-generation cephalosporins
Ceftiofur sodium is the sodium salt of ceftiofur, which belongs to the third generation cephalosporin antibiotics, for the first time in 1988 it was listed in the United States. Chemical properties are stabie, appearance is light yellow to white crystalline powder, aqueous solution has a shorter retention time, it should be diluted into a solution before use.
Ceftiofur has a broad antimicrobial spectrum , it has a strong antibacterial activity , it has a strong antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, and some anaerobic bacteria ,its antibacterial activity is similar to or weaker than the first-generation cephalosporins against Gram-positive bacteria , it has a strong antibacterial activity against Gram-negative bacteria such as E. coli, Salmonella, Pasteurella and so on. It is used for a variety of respiratory, urinary tract and other infections caused by sensitive bacteria, especially for the prevention and treatment of early death of chicks caused by E. coli, Salmonella, Pseudomonas aeruginosa, Staphylococcus aureus , E. coli yellow dysentery of 1 piglets and wound infections caused by cutting the umbilical cord, ear numbers, cutting teeth, tails and others, pleuropneumoniae and bovine bronchial pneumonia caused by Haemophilus and Actinobacillus , generally it does not apply to cows and goats mastitis treatment . Some researchers have done ceftiofur sodium inhibition tests for thousands strains of pathogens isolated by veterinary clinically , the results show that the drug is one of the most active anti-bacterial drugs, it has a strong antibacterial activity against Escherichia coli, p.multocida and p.haemolytica ,Bacillus typhosus, Streptococcus ; it also has a good effect on Pseudomonas aeruginosa, Enterobacter, anaerobic bacteria. It is used for the treatment of respiratory disease of sheep,horses, cattle, pigs (pleuropneumonia),and the treatment of pets, day-old broiler infectious diseases. This product has characteristics such as complete intramuscular absorption and long elimination half-life period .
The above information is edited by the lookchem of Tian Ye.
Veterinary Drugs and Treatments
Labeled indications for ceftiofur sodium:
In cattle for treatment of bovine respiratory disease (shipping
fever, pneumonia) associated with Mannheimia haemolytica,
Pasteurella multocida and Histophilus somni. It is also indicated
for treatment of acute bovine interdigital necrobacillosis (foot rot,
pododermatitis) associated with Fusobacterium necrophorum and
Bacteroides melaninogenicus.
In swine for treatment/control of swine bacterial respiratory
disease (swine bacterial pneumonia) associated with Actinobacillus
(Haemophilus) pleuropneumoniae, Pasteurella multocida, Salmonella
choleraesuis and Streptococcus suis.
In sheep/goats for treatment of sheep/caprine respiratory disease
(sheep/goat pneumonia) associated with Mannheimia haemolytica
and Pasteurella multocida.
In horses for treatment of respiratory infections in horses associated
with Streptococcus zooepidemicus.
In dogs for the treatment of canine urinary tract infections associated
with E. coli and Proteus mirabilis.
In day old chicks/poults for the control of early mortality, associated
with E. coli organisms susceptible to ceftiofur.
Ceftiofur sodium has also been used in an extra-label manner
in a variety of veterinary species (see Doses) to treat infections that
likely to be susceptible to a 3rd generation cephalosporin.
Check Digit Verification of cas no
The CAS Registry Mumber 104010-37-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,0,1 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 104010-37:
(8*1)+(7*0)+(6*4)+(5*0)+(4*1)+(3*0)+(2*3)+(1*7)=49
49 % 10 = 9
So 104010-37-9 is a valid CAS Registry Number.
InChI:InChI=1/C19H17N5O7S3.Na/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10;/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28);/q;+1/p-1/b23-11-;/t12-,16-;/m1./s1
