1169707-29-2 Usage
Description
(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)-2-buten-1-one is a complex organic compound characterized by a unique and specific chemical structure. It features functional groups such as triazolopyrazine, amino, and phenylethyl, along with fluorine-substituted aromatic rings. (2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)-2-buten-1-one holds potential in the pharmaceutical industry for the development of novel drugs and biologically active molecules due to its distinctive structural and functional attributes. Furthermore, it serves as a reference standard for analytical and research applications in organic chemistry.
Uses
Used in Pharmaceutical Industry:
(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)-2-buten-1-one is used as a precursor in the synthesis of novel drugs and biologically active molecules, leveraging its unique structure and functional groups to create new therapeutic agents.
Used in Organic Chemistry Research:
In the field of organic chemistry, (2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)-2-buten-1-one is utilized as a reference standard for analytical and research purposes, aiding in the study and understanding of complex organic compounds and their properties.
Check Digit Verification of cas no
The CAS Registry Mumber 1169707-29-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,9,7,0 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1169707-29:
(9*1)+(8*1)+(7*6)+(6*9)+(5*7)+(4*0)+(3*7)+(2*2)+(1*9)=182
182 % 10 = 2
So 1169707-29-2 is a valid CAS Registry Number.
1169707-29-2Relevant articles and documents
Practical and economical approach to synthesize sitagliptin
Lin, Kuaile,Cai, Zhengyan,Zhou, Weicheng
, p. 3281 - 3286 (2013)
Economic syntheses of sitagliptin phosphate monohydrate, acknowledged as the first dipeptidyl peptidase 4 (DPP-4) inhibitor, have been achieved in an overall yield of 42.4% in four steps from 1-{3-(trifluoromethyl)-5,6-dihydro-[1, 2,4]triazolo[4,3-a]pyrazin-7(8H)-yl}-4-(2,4,5-trifluorophenyl)butane-1,3-dione. The key stereoselective reduction of this process was carried out by NaBH 4/HCOOH instead of expensive and toxic catalysts or ligands. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
PREPARATION OF SITAGLIPTIN AND SALTS THEREOF
-
, (2011/04/14)
Processes for preparing sitagliptin and its pharmaceutically acceptable salts, and process intermediates.