117976-47-3 Usage
Description
Rabeprazole Sulfone is a metabolite of Rabeprazole, an off-white solid that is formed during the metabolism of the parent compound. It is a chemical derivative of Rabeprazole and is used for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
Rabeprazole Sulfone is used as a pharmaceutical impurity for Rabeprazole (R070500). It is an essential component in the development and manufacturing of Rabeprazole-based medications, ensuring the quality and safety of the final product.
Used in Research and Development:
Rabeprazole Sulfone is used as a research compound for studying the metabolism and pharmacokinetics of Rabeprazole. It helps researchers understand the drug's behavior in the body and its potential side effects, leading to the development of safer and more effective medications.
Used in Quality Control:
Rabeprazole Sulfone is used as a reference standard in the quality control and analysis of Rabeprazole-based pharmaceutical products. It helps ensure that the active pharmaceutical ingredient (API) meets the required specifications and is free from impurities.
Used in Metabolism Studies:
Rabeprazole Sulfone is used as a metabolite in the study of Rabeprazole's metabolic pathways. Understanding the metabolic fate of Rabeprazole can provide valuable insights into drug interactions, drug resistance, and the development of personalized medicine strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 117976-47-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,9,7 and 6 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 117976-47:
(8*1)+(7*1)+(6*7)+(5*9)+(4*7)+(3*6)+(2*4)+(1*7)=163
163 % 10 = 3
So 117976-47-3 is a valid CAS Registry Number.
InChI:InChI=1/C18H21N3O4S/c1-13-16(19-9-8-17(13)25-11-5-10-24-2)12-26(22,23)18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)
117976-47-3Relevant articles and documents
Synthesis of metabolites and related substances of rabeprazole, an anti-ulcerative drug
Reddy, Ganta Madhusudhan,Mukkanti, Kaga,Bhaskar, Boluggodu Vijaya,Reddy, Padi Pratap
, p. 278 - 290 (2009)
Rabeprazole sodium (Aciphex) is a gastric proton pump inhibitor used for the prevention and treatment of gastric acid-related diseases. During the synthesis of bulk drug of rabeprazole sodium, we have observed metabolites rabeprazole sulfide and rabeprazole sulfone and related substances rabeprazole-N-oxide, rabeprazole sulfone-N-oxide, N-aralkyl rabeprazole, chloro rabeprazole, and methoxy rabeprazole as impurities in the drug substance. The present work describes the synthesis and characterization of these compounds. Copyright Taylor & Francis Group, LLC.
Rabeprazole correlate D synthetic method
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Paragraph 0020; 0043-0047, (2018/12/13)
The present invention relates to a rabeprazole correlate D synthesis method, which comprises that: (1) in the presence of an excess oxidizing agent, a thioether compound 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridyl]methyl]thio]benzimidazole is oxidized to produce an oxide C; and (2) in the presence of an acid and a reducing agent, the oxide C formed in the step (1) is reduced so as to form the rabeprazole correlate D.
Synthetic studies connected with the preparation of H+/K +-ATPase inhibitors rabeprazole and lansoprazole
Radl, Stanislav,Klecan, Ondrej,Havlicek, Jaroslav
, p. 1447 - 1453 (2007/10/03)
Synthesis of lansoprazole and rabeprazole using common intermediates is devised. The common intermediates, 2-[(4-nitro-3-methylpyridin-2-yl) methanesulfanyl]-1H-benzoimidazole and 2-[(4-chloro-3-methyl-pyridin-2-yl) methanesulfanyl]-1H-benzoimidazole, were prepared in several ways.
