1186026-24-3

Basic information

• Product Name: C₂₉H₂₈⁽²⁾H₄ClN₅O₂
• Synonyms: C₂₉H₂₈⁽²⁾H₄ClN₅O₂
• CAS NO: 1186026-24-3
• Molecular Weight: 522.027
• Mol File: 1186026-24-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₂₈⁽²⁾H₄ClN₅O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₂₈⁽²⁾H₄ClN₅O₂(1186026-24-3)
• EPA Substance Registry System: C₂₉H₂₈⁽²⁾H₄ClN₅O₂(1186026-24-3)

Safety Data

• Hazardous Substances Data: 1186026-24-3(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 81935-60-6 2-methoxy-7-chloro-10-(4'-hydroxyphenyl)aminobenzo[b]-1,5-naphthyridine 
• 1664-98-8 paraformaldehyde-d2 

Relevant articles and documents

Synthesis of [2H]- and [13C]-labeled pyronaridine tetraphosphate - An antimalarial drug

The increasing prevalence of strains of Plasmodium falciparum resistant to chloroquine and other antimalarial drugs, necessitates the need for developing novel antimalarial drugs with a potent pharmacological activity. Pyronaridine tetraphosphate (PNDP) is one such drug that is currently undergoing preclinical and clinical trials for use in a chemotherapy treatment of malaria. The present investigation was carried out with the objective of synthesizing carbon-13 [13C]- and deuterium [2H]-labeled PNDP for use in studying the ADME and pharmacokinetics of the drug. Here, we present a methodology to synthesize [13C]- and [2H]-PNDP using a microwave irradiation technique as this method was found to be more advantageous than the classical method. The labeled compounds thus synthesized had a chemical purity of >99% as determined by HPLC and were also found to be relatively stable up to 3 months when stored under standard conditions. Further they also revealed satisfactory instrumental analysis data. Copyright