1189790-57-5

Basic information

• Product Name: 4-((4-(4-iodo-2,6-dimethylphenoxy)pyrimidin-2-yl)amino) benzonitrile
• Synonyms: 4-((4-(4-iodo-2,6-dimethylphenoxy)pyrimidin-2-yl)amino) benzonitrile
• CAS NO: 1189790-57-5
• Molecular Weight: 442.259
• Mol File: 1189790-57-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4-((4-(4-iodo-2,6-dimethylphenoxy)pyrimidin-2-yl)amino) benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((4-(4-iodo-2,6-dimethylphenoxy)pyrimidin-2-yl)amino) benzonitrile(1189790-57-5)
• EPA Substance Registry System: 4-((4-(4-iodo-2,6-dimethylphenoxy)pyrimidin-2-yl)amino) benzonitrile(1189790-57-5)

Safety Data

• Hazardous Substances Data: 1189790-57-5(Hazardous Substances Data)

Upstream product

• 10570-67-9 4-iodo-2,6-dimethylphenol 
• 244768-32-9 4-[(4-chloro-2-pyrimidinyl)amino]benzonitrile 
• 873-74-5 4-Aminobenzonitrile 

Downstream Products

• 1189790-58-6 4-(4-{4-[3-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)prop-1-ynyl]-2,6-dimethylphenoxy}pyrimidin-2-ylamino)benzonitrile 

Relevant articles and documents

Design, synthesis, and antiviral evaluation of chimeric inhibitors of HIV reverse transcriptase

In a continuing study of potent bifunctional anti-HIV agents, we rationally designed a novel chimeric inhibitor utilizing thymidine (THY) and a TMC derivative (a diarylpyrimidine NNRTI) linked via a polymethylene linker (ALK). The nucleoside, 5′-hydrogen-phosphonate (H-phosphonate), and 5′-triphosphate forms of this chimeric inhibitor (THY-ALK-TMC) were synthesized and the antiviral activity profiles were evaluated at the enzyme and cellular level. The nucleoside triphosphate (11) and the H-phosphonate (10) derivatives inhibited RT polymerization with an IC50 value of 6.0 and 4.3 nM, respectively. Additionally, chimeric nucleoside (9) and H-phosphonate (10) derivatives reduced HIV replication in a cell-based assay with low nanomolar antiviral potencies.

Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses

To further explore the chemical space surrounding the “hydrophobic channel” of the NNRTI binding pocket (NNIBP), a new series of diarylpyrimidines (DAPYs) were designed and synthesized as potent HIV-1 non-nucleoside RT inhibitors (NNRTIs). The target comp

Substituted 1,2,3 triazole diarylpyrimidine derivative as well as preparation method and application thereof

The invention discloses a substituted 1,2,3 triazole diarylpyrimidine derivative as well as a preparation method and application thereof. The substituted 1,2,3 triazole diarylpyrimidine derivative orpharmaceutically acceptable salts or prodrugs thereof ha