1227480-13-8

Basic information

• Product Name: 2,5-bis(4-(trifluoromethyl)phenyl)oxazole
• Synonyms: 2,5-bis(4-(trifluoromethyl)phenyl)oxazole
• CAS NO: 1227480-13-8
• Molecular Weight: 357.255
• Mol File: 1227480-13-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,5-bis(4-(trifluoromethyl)phenyl)oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-bis(4-(trifluoromethyl)phenyl)oxazole(1227480-13-8)
• EPA Substance Registry System: 2,5-bis(4-(trifluoromethyl)phenyl)oxazole(1227480-13-8)

Safety Data

• Hazardous Substances Data: 1227480-13-8(Hazardous Substances Data)

Upstream product

• 288-42-6 oxazol 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 455-13-0 4-Iodobenzotrifluoride 

Relevant articles and documents

Reaction Conditions for the Regiodivergent Direct Arylations at C2- or C5-Positions of Oxazoles using Phosphine-Free Palladium Catalysts

Two sets of reaction conditions for the regiodivergent C2- or C5- direct arylations of oxazole are reported. In both cases, phosphine-free catalysts and inexpensive bases were employed allowing the access to the arylated oxazoles in moderate to high yields. Using Pd(OAc)2/KOAc as catalyst and base, regioselective C5-arylations were observed; whereas, using Pd(acac)2/Cs2CO3 system, the arylation occurred at the C2-position of oxazole. The higher reactivity of C5-H bond of oxazole as compared to the C2-H bond in the presence of Pd(OAc)2/KOAc system is consistent with a concerted metalation deprotonation mechanism; whereas the C2-arylation likely occurs via a simple base deprotonation of the oxazole C2-position. Then, from these C2- or C5-arylated oxazoles, a second palladium-catalyzed direct C?H bond arylation affords 2,5-diaryloxazoles with two different aryl groups. We also applied these sequential arylations to the straightforward synthesis of 2-arylphenanthro[9,10-d]oxazoles via three C?H bond functionalization steps. The Ru-catalyzed C?H arylation of the aryl unit of 2-aryloxazoles is also described. (Figure presented.).

Direct multiple C-H bond arylation reaction of heteroarenes catalyzed by cationic palladium complex bearing 1,10-phenanthroline

A cationic palladium complex bearing 1,10-phenanthroline ligand is found to catalyze direct C-H arylation reactions of heteroarenes with aryl iodides to give mono-, di-, or tri-arylated products selectively. The Royal Society of Chemistry.