136239-68-4

Basic information

• Product Name: 1-HYDROXY-4-BUTOXY-2,3-DIFLUOROBENZENE
• Synonyms: 1-HYDROXY-4-BUTOXY-2,3-DIFLUOROBENZENE;4-Butoxy-2,3-difluorophenol
• CAS NO: 136239-68-4
• Molecular Formula: C10H12F2O2
• Molecular Weight: 202.2
• Mol File: 136239-68-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 268.9°Cat760mmHg
• Flash Point: 130.1°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 0.00451mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: 2-8°C
• PKA: 8.13±0.25(Predicted)
• CAS DataBase Reference: 1-HYDROXY-4-BUTOXY-2,3-DIFLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-HYDROXY-4-BUTOXY-2,3-DIFLUOROBENZENE(136239-68-4)
• EPA Substance Registry System: 1-HYDROXY-4-BUTOXY-2,3-DIFLUOROBENZENE(136239-68-4)

Safety Data

• Hazardous Substances Data: 136239-68-4(Hazardous Substances Data)

Usage

General Description

1-Hydroxy-4-Butoxy-2,3-Difluorobenzene is a chemical compound with the molecular formula C10H11F2O2. It is a colorless liquid with a molecular weight of 202.18 g/mol. 1-HYDROXY-4-BUTOXY-2,3-DIFLUOROBENZENE is often used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a solvent in various chemical processes. The chemical structure of 1-Hydroxy-4-Butoxy-2,3-Difluorobenzene contains a hydroxyl group, a butoxy group, and two fluorine atoms attached to a benzene ring. It is important to handle this compound with care, as it may be harmful if ingested, inhaled, or enters the skin. Proper safety measures should be taken when working with 1-Hydroxy-4-Butoxy-2,3-Difluorobenzene to avoid any potential health hazards.

InChI:InChI=1/C10H12F2O2/c1-2-3-6-14-8-5-4-7(13)9(11)10(8)12/h4-5,13H,2-3,6H2,1H3

Upstream product

• 136239-66-2 2,3-difluorophenyl butyl ether 
• 156487-12-6 4-butoxy-2,3-difluorobenzeneboronic acid 

Relevant articles and documents

Synthesis process of 2, 3-difluoro-4-alkoxy phenol

The invention discloses a synthesis process of 2, 3-difluoro-4-alkoxy phenol, and belongs to the technical field of organic synthesis. The process comprises the following steps: using 2, 3-difluorophenylalkyl ether as a raw material, carrying out lithiation by use of n-butyllithium under an ultralow temperature condition, reacting with boric acid ester, adding an alkali for quenching to obtain 2,3-difluoro-4-alkoxy benzene borate, oxidizing in the presence of hydrogen peroxide, and performing acidolysis to obtain 2, 3-difluoro-4-alkoxy phenol, so that the purity of the purified product can reach more than 99.95 %, the impurity content is less than 50ppm, and the requirements of electronic-grade products are met. Boric acid and the alkali can form salt, the salt is dissolved in water and subjected to a homogeneous reaction for an oxidation reaction during oxidation in the presence of the hydrogen peroxide, the reaction conditions are mild, impurities are few, the product purity is high, the solvent can be recycled, and industrial production is easy to achieve.

Process for the preparation of 2,3-difluorobenzenes

1,4-disubstituted 2,3-difluorobenzenes according to formula I are suitable as intermediates for the synthesis of liquid crystalline compounds.