138514-31-5Relevant articles and documents
A process for the preparation of intermediates esterspore proper logical sequence
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Paragraph 0030-0032, (2017/01/26)
The invention discloses a synthesis method of a drug intermediate, and particularly relates to a preparation method of a cefditoren pivoxil cephalosporins intermediate. The preparation method comprises the step of reacting through phosphorus Ylide-Wittig reaction and hydrolysis reaction by using 7-phenylacetamide-3-chloromethylcephalosporanic acid p-methoxybenzyl ester to obtain cefditoren pivoxil cephalosporins. The preparation method is simple in process, safe, environment-friendly, high in yield, and suitable for industrialized production.
AN IMPROVED PROCESS FOR THE PREPARATION OF CEFDITOREN
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Page 9, (2010/02/10)
The present invention relates to an improved process for the preparation of Cefditoren of formula (I), the said process comprising the steps of: i) converting the compound of formula (II) to a compound of the formula (III) using TPP and sodium iodide in the presence of THF, water, and base; ii) reacting the compound of formula (III) with 4-methyl-5-formyl-thiazole to produce a compound of formula (IV); iii) deesterifying the compound of the formula (IV) to yield compound of formula (V); iv) converting the compound of formula (V) to compound of formula (VI) in the presence of a base and solvent; v) converting the compound of formula (VI) into compound of formula (VII) by enzymatic hydrolysis; and vi) reacting compound of formula (VII) with compound of formula (VIII) in the presence of solvent and base to produce compound of formula (I).