14003-46-4 Usage
Description
2-(quinolin-4-yl)acetonitrile is an organic compound with the molecular formula C12H8N2. It is a derivative of quinoline, featuring a nitrile functional group attached to the second carbon atom. 2-(quinolin-4-yl)acetonitrile is known for its potential applications in various chemical and pharmaceutical processes due to its unique structure and reactivity.
Uses
Used in Pharmaceutical Industry:
2-(quinolin-4-yl)acetonitrile is used as a synthetic reagent for the development of potential bone morphogenetic protein (BMP) signaling inhibitors. These inhibitors play a crucial role in regulating the BMP signaling pathway, which is involved in various cellular processes, including cell proliferation, differentiation, and apoptosis. By targeting this pathway, these inhibitors can potentially be used in the treatment of diseases characterized by abnormal cell growth or tissue repair, such as cancer and osteoporosis.
Additionally, 2-(quinolin-4-yl)acetonitrile can be utilized in the synthesis of other bioactive compounds with potential applications in the pharmaceutical industry. Its unique structure allows for the development of novel drugs with improved efficacy and selectivity, contributing to the advancement of therapeutic options for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 14003-46-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,0,0 and 3 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 14003-46:
(7*1)+(6*4)+(5*0)+(4*0)+(3*3)+(2*4)+(1*6)=54
54 % 10 = 4
So 14003-46-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H8N2/c12-7-5-9-6-8-13-11-4-2-1-3-10(9)11/h1-4,6,8H,5H2
14003-46-4Relevant articles and documents
INHIBITORS OF THE BMP SIGNALING PATHWAY
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, (2009/10/22)
The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.
An improved method for direct conversion of heteroaryl-aldehydes to heteroaryl-acetonitriles
Engler, Thomas A.,Furness, Kelly,Malhotra, Sushant,Diefenbacher, Clive,Clayton, Joshua R.
, p. 2903 - 2905 (2007/10/03)
Treatment of heteroaryl-aldehydes with diethyl cyanophosphonate in the presence of a catalytic amount of LiCN affords phosphorylated cyanohydrins which are reduced in situ with SmI2 to give heteroaryl-acetonitriles in generally good overall yields (50-100%). The generality of the process is demonstrated.