142634-90-0

Basic information

• Product Name: 1-Acetylspiro-2'(1')-one
• CAS NO: 142634-90-0
• Molecular Weight: 229.279
• Mol File: 142634-90-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Acetylspiro-2'(1')-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Acetylspiro-2'(1')-one(142634-90-0)
• EPA Substance Registry System: 1-Acetylspiro-2'(1')-one(142634-90-0)

Safety Data

• Hazardous Substances Data: 142634-90-0(Hazardous Substances Data)

Upstream product

• 628-21-7 1,4-Diiodobutane 
• 21905-78-2 N-acetyloxindole 
• 150370-70-0 5-Acetyl-1,2,3,4-tetrahydro-4a,9b-epidioxycarbazole 
• 942-01-8 1,2,3,4-tetrahydrocarbazole 
• 142634-87-5 1-Acetyl-1,2,3,4-tetrahydrocarbazole 2,3-epoxide 
• 13815-69-5 N-acetyl-1,2,3,4-tetrahydrocarbazole 

Downstream Products

• 41058-67-7 spiro[cyclopentane-1,3'-indol]-2'(1'H)-one 

Relevant articles and documents

3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents

A series of substituted phenethyl derivatives of 3- benzisothiazolylpiperazine incorporating potent D2 and 5-HT(2A) antagonist activity was investigated as an approach to a novel atypical antipsychotic agent. The in vitro profile of 8e from this series is a combination of D2 receptor affinity comparable to the typical antipsychotic agent haloperidol and a 5-HT(2A)/D2 ratio comparable to the atypical agent clozapine. In vivo 8e possesses activity consistent with an efficacious antipsychotic agent with less tendency to induce extrapyramidal side effects in man.

Oxidation of N-Acylindoles by Dimethyldioxirane and Singlet Oxygen: Substituent Effects on Thermally Persistent Indole Epoxides and Dioxetanes

Photooxygenation of the N-acylindoles 1a-d afforded the labile indole dioxetanes 2 and the relatively stable allylic hydroperoxides 3.The dioxetanes 2a,c,d were sufficiently stable for isolation and spectral characterization.Additionally, they were characterized by chemical transformations, namely reduction to the indole epoxides 5 by dimethyl sulfide, acid-catalyzed rearrangement to allylic hydroperoxides 3c,d, and thermolysis to the cleavage products 4.Oxidation of the N-acylindoles 1 with dimethyldioxirane afforded the epoxides 5, which were characterized on the basis of their spectral data and chemical transformations to the 2-indolinones 6 and 2-methyleneindoline 7.These decomposition products (except 7e) were fully characterized.The stability of the epoxides 5 depended on the substitution type, i.e., the carbazole epoxide 5c decomposed already at temperatures above ca. -50 deg C, whereas the cyclopentindole epoxide 5b was stable at 20 deg C for days.The latter was unequivocally characterized by X-ray analysis.

Dimethyldioxirane Oxidation of Indole Derivatives. Formation of Novel Indole-2,3-epoxides and a Versatile Synthetic Route to Indolinones and Indolines

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