1435-50-3

Basic information

• Product Name: 2-Bromo-1,4-dichlorobenzene
• Synonyms: 2-BROMO-1,4-DICHLOROBENZENE;2,5-DICHLOROBROMOBENZENE;1-BROMO-2,5-DICHLOROBENZENE;Benzene, 1-bromo-2,5-dichloro-;2-Bromo-1,4-dichlorobenzene, 98+%;2,5-Dichlorophenyl bromide;1-Bromo-2,5-dichlorobenzene,99%;2-Bromo-1,4-dichloro
• CAS NO: 1435-50-3
• Molecular Formula: C₆H₃BrCl₂
• Molecular Weight: 225.9
• EINECS: 215-859-9
• Product Categories: Bromine Compounds;Chlorine Compounds
• Mol File: 1435-50-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 32-36 °C(lit.)
• Boiling Point: 118-120°C 20mm
• Flash Point: >230 °F
• Appearance: white to light yellow crystal powder
• Density: 1.6351 (rough estimate)
• Vapor Pressure: 0.0736mmHg at 25°C
• Refractive Index: 1.5700 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: insoluble
• BRN: 1934815
• CAS DataBase Reference: 2-Bromo-1,4-dichlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-1,4-dichlorobenzene(1435-50-3)
• EPA Substance Registry System: 2-Bromo-1,4-dichlorobenzene(1435-50-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38
• Safety Statements: 26-36-28A
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1435-50-3(Hazardous Substances Data)

Usage

Description

2-Bromo-1,4-dichlorobenzene is an organic compound that exists as a white to light yellow crystal powder. It is characterized by the presence of a bromine atom and two chlorine atoms attached to a benzene ring.

Uses

Used in Pharmaceutical Industry:
2-Bromo-1,4-dichlorobenzene is used as a reactant for the synthesis of C-13 and C-14-labeled versions of the investigational proteasome inhibitor MLN9708. This application is significant as it aids in the development of new drugs and therapies for various medical conditions.

InChI:InChI=1/C6H3BrCl2/c7-5-3-4(8)1-2-6(5)9/h1-3H

Upstream product

• 95-82-9 2,5 dichloroaniline 
• 88-42-6 2,5-dichlorobenzenesulfonic acid 
• 106-46-7 para-dichlorobenzene 
• 1940-27-8 2,5-dichloro-4-bromo-aniline 
• 15470-55-0 2,5-dichlorobenzenediazonium 
• 71-43-2 benzene 
• 89-61-2 2,5-dichloronitrobenzene 
• 199608-48-5 4-bromo-2,5-dichloroacetanilide 
• 22459-81-0 N-(4-bromo-3-chlorophenyl)acetamide 
• 873-38-1 4-chloro-2-bromoaniline 

Downstream Products

• 106-46-7 para-dichlorobenzene 
• 1984-58-3 2,5-dichloroanisole 
• 583-78-8 2,5-dichlorophenol 
• 68557-76-6 2-bromo-1,4-dichloro-3,5-dinitro-benzene 
• 170098-91-6 4-bromo-2,5-dichloronitrobenzene 
• 135145-90-3 2,5-dichlorobenzeneboronic acid 
• 100191-22-8 2,3-dibromo-1,4-dichlorobenzene 
• 1202503-92-1 1-(2,5-dichlorophenyl)-6-methoxyindan-1-ol 
• 13142-18-2 C₁₄H₁₂Cl₂N₂O 
• 13142-55-7 N-(2,5-dichlorophenyl)urea 
• 1613333-43-9 4-(4-(3-((2,5-dichlorophenyl)ethynyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine1-carboxylic acid tert-butyl ester 
• 1373162-11-8 C₈H₇BrCl₂ 
• 1373162-12-9 C₉H₁₀Cl₂ 
• 1373161-56-8 C₃₃H₃₆ 

Relevant articles and documents

A method for the synthesis of 2, 5 - dichlorophenol (by machine translation)

The invention relates to a 2, 5?Dichiorophenol synthetic method, which belongs to the technical field of the synthesis of the key intermediate chamber. The invention is composed of a pure chlorization generated 1, 2, 4?Trichlorobenzene and santochlor is easy to separate, thereby avoiding the difficulties caused by the separating of the high production cost and low production efficiency; because the 1, 2, 4?Trichlorobenzene and to two chiorophenoxy can be obtained respectively 2, 5?Dichiorophenol, utilization rate of raw materials is high, thereby avoiding the waste of the by-product, so that the production cost is greatly reduced. In addition, the two paradichlorbenzene through two different method to obtain 2, 5?Dichiorophenol. The synthesis technique of this invention is simple, the production cost is low, the utilization rate of raw materials is high, and the craft there are few by-products, less generation of three wastes, is more suitable for large-scale industrial production. (by machine translation)

Synthesis of symmetrical dinitro-and diamino-substituted Troeger's base analogues

This report describes a new synthetic approach to symmetrical diamino-substituted Troeger's base analogues, allowing the synthesis of 1,7-, and 4,10-diamino derivatives with no additional substituents and of 3,9-diamino derivative with methyl groups in the 1-, 4-, 7-and 10-positions. The synthesis uses regioselective nitration of dihalo-substituted-or tetrahalo-substituted Troeger's bases followed either by hydrogenation of the nitro functions accompanied by removal of halogen atoms or alternatively by chemoselective reduction of nitro groups to obtain the dihalo-diamino- substituted Troeger's base analogues. The 2,8-diamino derivatives, not accessible by this approach, can be prepared by Buchwald-Hartwig amination of the 2,8-dibromo-substituted Troeger's bases.

Use of Potassium Bromate: Bromination of Halobenzenes and Halobenzoic Acids

Syntheses of bromo compounds by the bromination of halobenzenes and halobenzoic acids using potassium bromate under acidic condition have been discussed.