1448431-93-3

Basic information

• Product Name: C₅₈H₇₈N₁₀O₁₂
• Synonyms: C₅₈H₇₈N₁₀O₁₂
• CAS NO: 1448431-93-3
• Molecular Weight: 1107.32
• Mol File: 1448431-93-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₈H₇₈N₁₀O₁₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₈H₇₈N₁₀O₁₂(1448431-93-3)
• EPA Substance Registry System: C₅₈H₇₈N₁₀O₁₂(1448431-93-3)

Safety Data

• Hazardous Substances Data: 1448431-93-3(Hazardous Substances Data)

Upstream product

• 113705-17-2 2,7-bis[2-(trimethylsilyl)ethynyl]naphthalene 
• 58556-75-5 2,7-dibromonaphthalene 
• 1443619-95-1 di-tert-butyl (((5-azido-1,3-phenylene)bis(oxy))bis(propane-3,1-diyl))dicarbamate 
• 113705-27-4 2,7-diethynylnaphthalene 
• 1382469-16-0 C₂₂H₃₅BrN₂O₆ 
• 83948-53-2 3-bromopropylamine tert-butylcarbamate 
• 106120-04-1 5-bromoresorcinol 

Relevant articles and documents

Expedient synthesis of SMAMPs via click chemistry

A novel series of synthetic mimics of antimicrobial peptides (SMAMPs) containing triazole linkers were assembled using click chemistry. While only moderately active in buffer alone, an increase in antimicrobial activity against Staphylococcus aureus and Escherichia coli was observed when these SMAMPs were administered in the presence of mouse serum. One compound had minimum inhibitory concentrations (MICs) of 0.39 μg/mL and 6.25 μg/mL, respectively, and an HC50 of 693 μg/mL. These values compared favorably to peptide-based antimicrobials. A correlation between the net positive charge and SMAMP antimicrobial activity was observed. The triazole linker, an amide surrogate, was found to provide better antimicrobial activity against both S. aureus and E. coli when compared to other analogues.