146404-45-7

Basic information

• Product Name: (2E,6E)-(4R,8R)-9-((1S,3R,4R)-4-Hydroxy-3-methoxy-cyclohexyl)-2,4,8-trimethyl-5-oxo-nona-2,6-dienal
• Synonyms: (2E,6E)-(4R,8R)-9-((1S,3R,4R)-4-Hydroxy-3-methoxy-cyclohexyl)-2,4,8-trimethyl-5-oxo-nona-2,6-dienal
• CAS NO: 146404-45-7
• Molecular Weight: 322.445
• Mol File: 146404-45-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2E,6E)-(4R,8R)-9-((1S,3R,4R)-4-Hydroxy-3-methoxy-cyclohexyl)-2,4,8-trimethyl-5-oxo-nona-2,6-dienal(CAS DataBase Reference)
• NIST Chemistry Reference: (2E,6E)-(4R,8R)-9-((1S,3R,4R)-4-Hydroxy-3-methoxy-cyclohexyl)-2,4,8-trimethyl-5-oxo-nona-2,6-dienal(146404-45-7)
• EPA Substance Registry System: (2E,6E)-(4R,8R)-9-((1S,3R,4R)-4-Hydroxy-3-methoxy-cyclohexyl)-2,4,8-trimethyl-5-oxo-nona-2,6-dienal(146404-45-7)

Safety Data

• Hazardous Substances Data: 146404-45-7(Hazardous Substances Data)

Upstream product

• 53123-88-9 sirolimus 
• 151695-69-1 (7E,15E,17E,19E)-(2R,3S,6R,9R,10R,12R,14S,21S)-3,9-Dihydroxy-1-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-10,21-dimethoxy-2,6,8,12,14,20-hexamethyl-22-((2S,5R)-5-methyl-6-oxo-tetrahydro-pyran-2-yl)-docosa-7,15,17,19-tetraene-5,11-dione 
• 146404-44-6 C₅₂H₈₁NO₁₄ 
• 147438-29-7 28-secorapamycin 

Relevant articles and documents

Base Catalyzed Degradations of Rapamycin

The base catalyzed degradation of rapamycin was re-examined and a sequence of steps involving β-elimination, retro-aldol cleavage and benzilic acid rearrangement occur leading to several new products.

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The reaction of rapamycin (1) and FK506 (11) with n-Bu4N+CN- / aq. THF results in an efficient excision of their pipecolinate subunits, leading in good yields to compounds 3 and 12, respectively. Two sequential ring cleava

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The degradation of rapamycin has made available key substructures which have defined the structures of advanced synthetic intermediates.