149104-89-2Relevant articles and documents
Scalable synthesis of [8]cycloparaphenyleneacetylene carbon nanohoop using alkyne metathesis
Bruns, Carson J.,Fronczek, Frank R.,Herman, Robert J.,Kwon, Hyejin,Lee, Semin,Thompson, Richard R.,Zhou, Xin
supporting information, p. 10887 - 10890 (2021/10/22)
Large scale synthesis of cycloparaphenyleneacetylenes has been challenging due to low macrocyclization yields and harsh aromatization methods that often decompose strained alkynes. Herein, acis-stilbene-based building block is subjected to alkyne metathes
STAT DEGRADERS AND USES THEREOF
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Paragraph 000968; 0001024; 0001025, (2020/10/19)
The present invention provides compounds, compositions thereof, and methods of using the same.
Small molecule compound
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Paragraph 0181-0184, (2020/01/12)
The invention provides a small molecular compound, The small molecular compound is characterized by having a structure as shown in the following molecular general formula, wherein X1 and X2 are selected from carbon or nitrogen, G1 is a carbon ring or a heterocyclic ring with aromaticity, any one or more hydrogen atoms on the G1 ring are substituted by R1, wherein R1 is selected from nitrogen-containing groups. The small molecule compound can be used as an efficient and specific JAK kinase inhibitor, especially a Tyk2 inhibitor, and/or a JAK1 inhibitor, and/or a JAK1/Tyk2 dual inhibitor, or a Tyk2/JAK1 dual inhibitor or a Tyk2/Jak2 dual inhibitor.