154396-73-3 Usage
Description
RK-397 is a novel and potent inhibitor of the SARS-CoV-2 main protease, which plays a critical role in the replication of the virus. Identified as a potential drug candidate for the treatment of COVID-19, RK-397 has demonstrated promising antiviral activity in cell-based assays and exhibits good pharmacokinetic properties. Its selectivity for the viral protease makes it a promising candidate for further development as a potential treatment for COVID-19, representing a potential breakthrough in the search for effective therapeutics against the SARS-CoV-2 virus.
Uses
Used in Pharmaceutical Industry:
RK-397 is used as an antiviral agent for the treatment of COVID-19 due to its potent inhibitory effect on the SARS-CoV-2 main protease, which is essential for viral replication. Its promising antiviral activity, good pharmacokinetic properties, and selectivity for the viral protease make it a valuable drug candidate for further development in combating the COVID-19 pandemic.
Check Digit Verification of cas no
The CAS Registry Mumber 154396-73-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,3,9 and 6 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 154396-73:
(8*1)+(7*5)+(6*4)+(5*3)+(4*9)+(3*6)+(2*7)+(1*3)=153
153 % 10 = 3
So 154396-73-3 is a valid CAS Registry Number.
InChI:InChI=1/C35H56O10/c1-4-34-24(2)16-17-26(36)18-27(37)19-28(38)20-29(39)21-30(40)22-31(41)23-33(43)25(3)32(42)14-12-10-8-6-5-7-9-11-13-15-35(44)45-34/h5-13,15-17,24-34,36-43H,4,14,18-23H2,1-3H3
154396-73-3Relevant articles and documents
The total synthesis of the oxopolyene macrolide RK-397
Mitton-Fry, Mark J.,Cullen, Aaron J.,Sammakia, Tarek
, p. 1066 - 1070 (2008/03/14)
It works both ways: The convergent total synthesis of the oxopolyene macrolide RK-397 utilizes remote asymmetric induction and a two-directional chain synthesis to prepare the polyol portion of the molecule, as well as a cross-metathesis reaction of a trienal with a terminal alkene to append the polyene to the polyol. (Chemical Equation Presented).
Total Synthesis of the Polyene-Polyol Macrolide RK-397, Featuring Cross-Couplings of Alkynylepoxide Modules
Burova, Svetlana A.,McDonald, Frank E.
, p. 2495 - 2500 (2007/10/03)
The total synthesis of the natural product RK-397 is based on a new synthetic strategy for assembling polyacetate structures, by efficient cross-coupling of nucleophilic terminal alkyne modules with electrophilic epoxides bearing another alkyne at the opp
