157373-08-5 Usage
Description
2,3,4-Trifluorobenzoyl chloride is an organic compound characterized by its clear colorless to pale yellow liquid appearance. It is a derivative of benzoyl chloride with three fluorine atoms substituted at the 2nd, 3rd, and 4th positions on the benzene ring. 2,3,4-TRIFLUOROBENZOYL CHLORIDE is known for its reactivity and is commonly utilized in the synthesis of various pharmaceuticals and organic compounds.
Uses
Used in Pharmaceutical Industry:
2,3,4-Trifluorobenzoyl chloride is used as a key reagent for the preparation of Levofloxacin, a widely prescribed antibiotic belonging to the fluoroquinolone class. Levofloxacin is effective against a broad spectrum of bacteria, making it a valuable component in treating various bacterial infections.
The use of 2,3,4-trifluorobenzoyl chloride in the synthesis of Levofloxacin highlights its importance in the pharmaceutical industry, as it contributes to the development of life-saving medications. Its unique chemical properties allow for specific reactions that facilitate the production of the desired antibiotic, showcasing its significance in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 157373-08-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,3,7 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 157373-08:
(8*1)+(7*5)+(6*7)+(5*3)+(4*7)+(3*3)+(2*0)+(1*8)=145
145 % 10 = 5
So 157373-08-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H2ClF3O/c8-7(12)3-1-2-4(9)6(11)5(3)10/h1-2H
157373-08-5Relevant articles and documents
Synthesis and evaluation of sensitive coumarin-based fluorogenic substrates for discovery of α-N-acetyl galactosaminidases through droplet-based screening
Chen, Hong-Ming,Nasseri, Seyed Amirhossein,Rahfeld, Peter,Wardman, Jacob F.,Kohsiek, Maurits,Withers, Stephen G.
supporting information, p. 789 - 793 (2021/02/09)
As part of a search for a substrate for droplet-based microfluidic screening assay of α-N-acetylgalactosaminidases, spectral and physical characteristics of a series of coumarin derivatives were measured. From among these a new coumarin-based fluorophore, Jericho Blue, was selected as having optimal characteristics for our screen. A reliable method for the challenging synthesis of coumarin glycosides of α-GalNAc was then developed and demonstrated with nine examples. The α-GalNAc glycoside of Jericho Blue prepared in this way was shown to function well under screening conditions.
NOVEL PROCESS FOR MAKING COMPOUNDS FOR USE IN THE TREATMENT OF CANCER
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Paragraph 000139, (2014/05/07)
Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.
