15761-39-4 Usage
Description
BOC-L-Proline, also known as N-Boc-L-proline, is a synthetic intermediate that serves as a crucial component in various chemical and pharmaceutical applications. It is a white to off-white microcrystalline powder, which has been utilized in the synthesis of enantioselective catalysts for aldol reactions and hepatitis C virus (HCV) NS5A inhibitors.
Uses
Used in Pharmaceutical Industry:
BOC-L-Proline is used as an intermediate in organic synthesis for the development of various pharmaceutical compounds. Its role in the synthesis of enantioselective catalysts for aldol reactions makes it a valuable component in the creation of new drugs and therapies.
Used in Hepatitis C Treatment:
BOC-L-Proline is used as a key component in the preparation of daclatasvir, a drug that inhibits the hepatitis C virus (HCV) non-structural 5A (NS5A) protein. This application aids in the treatment of hepatitis C virus infections, providing a crucial therapeutic option for patients suffering from this disease.
Used in Organic Synthesis:
BOC-L-Proline is employed as an intermediate in the synthesis of various organic compounds. Its versatility in chemical reactions allows for the development of a wide range of products, contributing to the advancement of the chemical industry and the creation of new materials and substances.
Preparation
Triethylamine (16.5 mL, 0.12 mmol) was added dropwise over a period of 10 min to a stirred, ice-cold suspension of l-proline (10.0 g, 8.7 mmol) in dichloromethane (200 mL) in a 500-mL three-necked, round-bottomed flask. A solution of Boc2O (28.3 g, 0.13 mmol) in dichloromethane (100 mL) was then added over a period of 10 min and the mixture was stirred for 2.5 h. Thereafter, 10% aqueous citric acid (50 mL) was added, and the dichloromethane layer was washed with saturated brine (2×50 mL) and with water (50 mL). After drying the organic phase over magnesium sulfate, the solvent was evaporated and the residue was taken up in hot ethyl acetate. Dilution of this solution with hexane gave the product, N-tertbutoxycarbonyl- L-proline (17.8 g, 95%); mp 138–140℃; TLC (silica gel): Rf=0:36 (EtOAc/MeOH, 1:1).
Check Digit Verification of cas no
The CAS Registry Mumber 15761-39-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,7,6 and 1 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 15761-39:
(7*1)+(6*5)+(5*7)+(4*6)+(3*1)+(2*3)+(1*9)=114
114 % 10 = 4
So 15761-39-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H17NO4/c1-10(2,3)15-9(14)11-6-4-5-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/p-1/t7-/m0/s1