1597486-87-7Relevant articles and documents
PROCESS FOR PREPARATION OF MK-7 TYPE OF VITAMIN K2
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, (2014/05/07)
Process for preparation of MK-7 type of vitamin K2 is characterized by attaching hexaprenyl chain of ?all-trans" configuration to monoprenyl derivative of menadiol following ?1 + 6" synthetic strategy. According to the invention, a-sulfonyl carbanion generated in situ from the protected monoprenyl menadiol of the formula (II), wherein R1 represents C1-3-alkyl group, is reacted with hexaprenyl halide of the formula (VII), wherein X represents halogen atom, preferably bromine, both Z' and Z' represent H or one of Z' and Z" represents H and the other represents phenylsulfonyl group -SO2Ph in the alkylation reaction. The hexaprenyl halide of formula (VII) is obtained by coupling two triprenyl units in alkylation reaction, with or without separation of the intermediates.