163391-76-2 Usage
Description
Stachybotrylactam is an unusual spirodihydrobenzofuranlactam mycotoxin derived from the Stachybotrys sp. It exhibits immunosuppressant properties and weak HIV protease activity. STACHYBOTRYLACTAM belongs to a structural class that demonstrates a range of activities, such as antiviral, endothelin, and pancreatic cholesterase inhibition.
Uses
Used in Pharmaceutical Industry:
Stachybotrylactam is used as an immunosuppressant for its ability to suppress the immune system, which can be beneficial in certain medical treatments where the immune response needs to be controlled or reduced.
Additionally, Stachybotrylactam is used as an inhibitor of HIV protease, which plays a crucial role in the replication of the HIV virus. By inhibiting this enzyme, the compound can help in the development of antiretroviral therapies.
Used in Antiviral Applications:
Stachybotrylactam is used as an antiviral agent due to its ability to inhibit the replication of various viruses, making it a potential candidate for the development of new antiviral drugs.
Used in Endothelin Inhibition:
Stachybotrylactam is used as an endothelin inhibitor, which can be beneficial in treating conditions related to endothelin overactivity, such as hypertension and certain cardiovascular diseases.
Used in Pancreatic Cholesterase Inhibition:
Stachybotrylactam is used as an inhibitor of pancreatic cholesterase, an enzyme involved in the breakdown of cholesterol. This inhibition can be useful in the development of treatments for hypercholesterolemia and other cholesterol-related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 163391-76-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,3,3,9 and 1 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 163391-76:
(8*1)+(7*6)+(6*3)+(5*3)+(4*9)+(3*1)+(2*7)+(1*6)=142
142 % 10 = 2
So 163391-76-2 is a valid CAS Registry Number.
163391-76-2Relevant articles and documents
Chartarolides A-C, novel meroterpenoids with antitumor activities
Liu, Dong,Li, Yong,Li, Xiaodan,Cheng, Zhongbin,Huang, Jian,Proksch, Peter,Lin, Wenhan
supporting information, p. 1826 - 1829 (2017/04/21)
Three phenylspirodrimane-based meroterpenoids with novel scaffolds, namely chartarolides A-C (1–3), were isolated from a sponge (Niphates recondite) associated fungus Stachybotrys chartarum WGC-25C-6. Their structures were determined on the basis of comprehensive analyses of the spectroscopic data (IR, 1D and 2D NMR, HRESIMS), including the TDDFT-ECD calculation for the assignments of absolute configurations. The biogenetic generation of 1–3 through the conjunction of phenylspirodrimane and mollicellin-type analogues as the precursors was postulated. Chartarolides A-C exhibited significant cytotoxic activities against a panel of human tumor cell lines, and showed strong inhibitory activities against the human tumor related protein kinases of FGFR3, IGF1R, PDGFRb, and TrKB.
Enantioselective total synthesis and structure revision of spirodihydrobenzofuranlactam 1. Total synthesis of stachybotrylactam
Kende, Andrew S.,Deng, Wei-Ping,Zhong, Min,Guo, Xiao-Chuan
, p. 1785 - 1788 (2007/10/03)
(Matrix presented) The enantioselective total synthesis and structure revision of spirodihydrobenzofuranlactam 1 and of its regioisomer 25 are presented. Optically pure (+)-Wieland-Miescher ketone was utilized to construct the AB bicyclic core in 10 steps