1710-55-0

Basic information

• Product Name: 2,3-dihydro-5-methoxy-1,4-benzodioxin
• Synonyms: 2,3-dihydro-5-methoxy-1,4-benzodioxin;5-Methoxy-2,3-dihydro-1,4-benzodioxin
• CAS NO: 1710-55-0
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.1739
• EINECS: 216-972-6
• Mol File: 1710-55-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 239.6°Cat760mmHg
• Flash Point: 78.2°C
• Appearance: /
• Density: 1.167g/cm³
• Vapor Pressure: 0.0613mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: 2,3-dihydro-5-methoxy-1,4-benzodioxin(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydro-5-methoxy-1,4-benzodioxin(1710-55-0)
• EPA Substance Registry System: 2,3-dihydro-5-methoxy-1,4-benzodioxin(1710-55-0)

Safety Data

• Hazardous Substances Data: 1710-55-0(Hazardous Substances Data)

Usage

Description

2,3-dihydro-5-methoxy-1,4-benzodioxin, also known as 5-Methoxy-1,4-benzodioxane, is a chemical compound characterized by the molecular formula C9H10O3. It is a white solid with a faint odor, featuring a dioxin ring with a methoxy substituent at the 5-position. 2,3-dihydro-5-methoxy-1,4-benzodioxin is recognized for its stability and low toxicity, which makes it a valuable asset in both research and industrial applications.

Uses

Used in Pharmaceutical Industry:
2,3-dihydro-5-methoxy-1,4-benzodioxin serves as a crucial intermediate in the synthesis of a variety of drugs. Its applications extend to the treatment of cardiovascular diseases and central nervous system disorders, highlighting its importance in medicinal chemistry.
Used in Organic Synthesis:
In the realm of organic synthesis, 2,3-dihydro-5-methoxy-1,4-benzodioxin acts as a building block for the preparation of complex organic molecules. Its structural attributes make it a versatile component in creating intricate chemical entities for various applications.

InChI:InChI=1/C9H10O3/c1-10-7-3-2-4-8-9(7)12-6-5-11-8/h2-4H,5-6H2,1H3

Upstream product

• 934-00-9 3-methocycatechol 
• 106-93-4 ethylene dibromide 

Downstream Products

• 260561-48-6 cis-4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid 
• 190661-82-6 5-bromo-8-methoxy-2,3-dihydrobenzo[b][1,4]dioxine 
• 10288-36-5 2,3-dihydro-1,4-benzodioxin-5-ol 

Relevant articles and documents

Urea substituted aromatic ring connected dioxane and quinazoline or quinoline compound, composition and application thereof (by machine translation)

The invention relates to a novel compound VEGFR - 2 composition as CSF1R and, inhibitors and application. thereof in particular, and provides a compound VEGFR - 2 with potent inhibition CSF1R and (and a pharmaceutical composition (1) containing the compound as shown) or an isomer, solvate, hydrate, of the compound in preparation of a medicament, of the compound or a pharmaceutical composition containing the compound. A compound or a pharmaceutical composition containing the compound in a pharmaceutically acceptable salt, comprises . g of a compound or, a pharmaceutical composition containing the. above compound in a pharmaceutically acceptable form. (by machine translation)

A practical synthesis of the PDE4 inhibitor, KW-4490

A practical and scalable synthesis of a PDE4 inhibitor KW-4490 (1) was developed. This improved synthesis features the construction of the 1-arylcyclohexene (9) by the Diels-Alder reaction followed by a newly established Brnsted acid-promoted hydrocyanation. Subsequent crystallization-induced dynamic resolution enabled the high-yield production of the desired cis-isomer (cis-8). The synthesis was achieved in seven steps in 37% overall yield.

DERIVATIVES OF BENZOFURAN OR BENZODIOXOLE

An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R1 and R2 independently represent hydrogen, lower alkyl, cyano, —(CH2)n—E1—CO—G1 (wherein E1 represents a bond, O, or NH; and G1 represents hydrogen, substituted or unsubstituted lower alkyl, OR6, or NR7R8; and n represents an integer of 0 to 4), or the like; R1 and R2 are combined to represent a saturated carbon ring together with a carbon atom adjacent thereto; or R2, and R11 or R13 described below are combined to form a single bond; R3 represents hydrogen, phenyl, or halogen; R4 represents hydroxy, lower alkoxy, or the like; A represents —C(R9)(R10)— or O; B represents O, NR11, —C(R12)(R13)—, or —C(R14)(R15)—C(R16)(R17)—; D represents (i) —C(R18)(R19)—X— (wherein X represents —C(R21)(R22)—, S, or NR23), (ii) —C(R19a)═Y— [Y represents —C(R24)—Z— (wherein Z represents CONH, CONHCH2, or a bond), or N], or (iii) a bond; and R5 represents aryl, an aromatic heterocyclic group, cycloalkyl, pyridine-N-oxide, cyano, or lower alkoxycarbonyl; or pharmaceutically acceptable salts thereof.