171032-87-4

Basic information

• Product Name: (S)-1-(2-FLUOROPHENYL)ETHANOL
• Synonyms: (S)-2'-Fluorophenylethan-1-ol;(1S)-1-(2-Fluorophenyl)ethan-1-ol;(S)-2-Fluoro-alpha-methylbenzyl alcohol;(S)-1-(2-FLUOROPHENYL)ETHANOL;S-OF-PEL;Benzenemethanol, 2-fluoro-alpha-methyl-, (alphaS)- (9CI);(S)-1-(2-Ffluorophenyl)ethanol;(1S)-1-(2-Fluorophenyl)ethanol
• CAS NO: 171032-87-4
• Molecular Formula: C₈H₉FO
• Molecular Weight: 140.15
• Product Categories: HALIDE;Alcohols, Hydroxy Esters and Derivatives;Chiral Compounds
• Mol File: 171032-87-4.mol
• Article Data: 112

Chemical Properties

• Boiling Point: 193℃
• Flash Point: 88℃
• Appearance: /
• Density: 1.123
• Vapor Pressure: 0.297mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.95±0.20(Predicted)
• CAS DataBase Reference: (S)-1-(2-FLUOROPHENYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(2-FLUOROPHENYL)ETHANOL(171032-87-4)
• EPA Substance Registry System: (S)-1-(2-FLUOROPHENYL)ETHANOL(171032-87-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 171032-87-4(Hazardous Substances Data)

Usage

Description

(S)-1-(2-FLUOROPHENYL)ETHANOL is an organic compound that serves as a crucial building block in the synthesis of various pharmaceuticals and organic compounds. Its unique structure, featuring a fluorophenyl group attached to an ethanol moiety, endows it with specific properties that make it valuable in the development of new drugs and other organic compounds.

Uses

Used in Pharmaceutical Industry:
(S)-1-(2-FLUOROPHENYL)ETHANOL is used as a key building block in the synthesis of pharmaceuticals for its ability to contribute to the development of novel drugs with unique therapeutic properties. One notable example is its application in the creation of JN403, a novel nicotinic acetylcholine receptor α7 agonist. (S)-1-(2-FLUOROPHENYL)ETHANOL has potential applications in the treatment of various neurological disorders and cognitive impairments, highlighting the importance of (S)-1-(2-FLUOROPHENYL)ETHANOL in advancing pharmaceutical research and development.
Additionally, due to its versatility in organic synthesis, (S)-1-(2-FLUOROPHENYL)ETHANOL can be utilized in the production of other bioactive molecules, further expanding its applications across different areas of the pharmaceutical industry. Its presence in the synthesis process can lead to the discovery of new drugs with improved efficacy, safety, and selectivity, ultimately benefiting patients and healthcare providers alike.

InChI:InChI=1/C8H9FO/c1-6(10)7-4-2-3-5-8(7)9/h2-6,10H,1H3/t6-/m0/s1

Upstream product

• 445-27-2 2'-Fluoroacetophenone 
• 445-26-1 1-(2-fluorophenyl)ethanol 
• 394-46-7 2-fluorostyrene 
• 274-07-7 benzo[1,3,2]dioxaborole 
• 108-05-4 vinyl acetate 
• 766-49-4 (2-fluorophenyl)acetylene 
• 1796-63-0 1-<2-Fluorphenyl>-ethyl-acetat 
• 67-63-0 isopropyl alcohol 
• 934226-04-7 (S)-1-(2-fluorophenyl)ethyl alcohol phthalate half ester 
• 75-16-1 methylmagnesium bromide 
• 446-52-6 2-Fluorobenzaldehyde 
• 544-97-8 dimethyl zinc(II) 
• 75-24-1 trimethylaluminum 

Downstream Products

• 1181364-55-5 imidazole-1-carboxylic acid (S)-1-(2-fluorophenyl)ethyl ester 
• 911716-08-0 2-amino-5-{[(1S)-1-(2-fluorophenyl)ethyl]thio}[1,3]thiazolo[4,5-d]pyrimidin-7-ol 
• 911716-09-1 7-chloro-5-{[(1S)-1-(2-fluorophenyl)ethyl]thio}[1,3]thiazolo[4,5-d]pyrimidin-2-amine 
• 911716-07-9 6-amino-2-{[(1S)-1-(2-fluorophenyl)ethyl]thio}pyrimidin-4-ol 
• 942606-12-4 JN 403 
• 1240815-56-8 (S)-(-)-1-(2-fluorophenyl)ethyl N,N-diisopropylcarbamate 
• 911716-00-2 1-[(1R)-1-chloroethyl]-2-fluorobenzene 

Relevant articles and documents

Biocatalytic reduction of ketones by a semi-continuous flow process using supercritical carbon dioxide

The immobilized resting-cell of Geotrichum candidum was used as a catalyst for the reduction of a ketone in a semi-continuous flow process using supercritical carbon dioxide for the first time; it was also applied for the asymmetric reduction of a ketone

Novel non-metal catalyst for catalyzing asymmetric hydrogenation of ketone and alpha, beta-unsaturated ketone

The invention discloses a novel non-metal catalyst for catalyzing asymmetric hydrogenation of ketone and alpha, beta-unsaturated ketone. The preparation method of a chiral alcohol compound shown as formula IV comprises the following step of: reacting a ketone compound shown as formula V with hydrogen under the catalysis of tri(4-hydrotetrafluorophenyl)boron and a chiral oxazoline compound to obtain the chiral alcohol compound shown as the formula IV; the preparation method of a chiral tetralone compound shown as formula VI comprises the following step of: under the catalysis of tri(4-hydrotetrafluorophenyl)boron and a chiral oxazoline compound, reacting an alpha, beta-unsaturated ketone compound shown as formula VII with hydrogen to obtain the chiral tetralone compound shown as the formula VI. The method has the advantages of easy synthesis of raw materials, mild reaction conditions, simple operation, high stereoselectivity and the like, the ee value of the product is up to 92%, and the yield is up to 99%.

Arene-Immobilized Ru(II)/TsDPEN Complexes: Synthesis and Applications to the Asymmetric Transfer Hydrogenation of Ketones

The Noyori-Ikariya (arene)Ru(II)/TsDPEN precatalyst has been anchored to amorphous silica and DAVISIL through the η6-coordinated arene ligand via a straightforward synthesis and the derived systems, (arene)Ru(II)/TsDPEN@silica and (arene)Ru(II)/TsDPEN@DAVISIL, form highly efficient catalysts for the asymmetric transfer hydrogenation of a range of electron-rich and electron-poor aromatic ketones, giving good conversion and excellent ee's under mild reaction conditions. Moreover, catalyst generated in situ immediately prior to addition of substrate and hydrogen donor, by reaction of silica-supported [(arene)RuCl2]2 with (S,S)-TsDPEN, was as efficient as that generated from its preformed counterpart [(arene)Ru{(S,S)-TsDPEN}Cl]@silica. Gratifyingly, the initial TOFs (up to 1085 h?1) and ee's (96–97 %) obtained with these catalysts either rivalled or outperformed those previously reported for catalysts supported by either silica or polymer immobilized through one of the nitrogen atoms of TsDPEN. While the high ee's were also maintained during recycle studies, the conversion dropped steadily over the first three runs due to gradual leaching of the ruthenium.