1826-14-8

Basic information

• Product Name: 2,4-DIPHENYLTHIAZOLE
• Synonyms: 2,4-DIPHENYLTHIAZOLE
• CAS NO: 1826-14-8
• Molecular Formula: C₁₅H₁₁NS
• Molecular Weight: 237.31954
• Mol File: 1826-14-8.mol
• Article Data: 44

Chemical Properties

• Melting Point: 92.5°C
• Appearance: /
• Density: 1.1554
• Refractive Index: 1.5300 (estimate)
• CAS DataBase Reference: 2,4-DIPHENYLTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIPHENYLTHIAZOLE(1826-14-8)
• EPA Substance Registry System: 2,4-DIPHENYLTHIAZOLE(1826-14-8)

Safety Data

• Hazardous Substances Data: 1826-14-8(Hazardous Substances Data)

Usage

Description

2,4-DIPHENYLTHIAZOLE, also known as diphenylthiazole, is a chemical compound with the molecular formula C15H11NS. It belongs to the thiazole class of compounds and is commonly synthesized for use in organic synthesis and pharmaceutical research. 2,4-DIPHENYLTHIAZOLE is known for its potential applications in the development of new drugs and serves as a building block in the synthesis of various organic compounds. Its antimicrobial, antiviral, and antitumor properties have garnered interest in the pharmaceutical and life sciences industries. Furthermore, 2,4-DIPHENYLTHIAZOLE's photophysical and electrochemical properties make it valuable for materials science and nanotechnology research.

Uses

Used in Pharmaceutical Research and Drug Development:
2,4-DIPHENYLTHIAZOLE is used as a key intermediate in the synthesis of new drugs for its potential antimicrobial, antiviral, and antitumor properties. It aids in the development of pharmaceuticals targeting a range of diseases and conditions.
Used in Organic Synthesis:
2,4-DIPHENYLTHIAZOLE is used as a building block in the synthesis of various organic compounds, contributing to the creation of complex molecules with diverse applications.
Used in Materials Science and Nanotechnology Research:
2,4-DIPHENYLTHIAZOLE is used as a component in the study of photophysical and electrochemical properties, facilitating advancements in material development and nanotechnology applications.
Used in Antimicrobial Applications:
2,4-DIPHENYLTHIAZOLE is used as an antimicrobial agent for its ability to combat various types of microorganisms, contributing to the development of new treatments and preventive measures against infections.
Used in Antiviral Applications:
2,4-DIPHENYLTHIAZOLE is used as an antiviral agent, leveraging its properties to inhibit viral replication and spread, offering potential therapeutic solutions for viral diseases.
Used in Antitumor Applications:
2,4-DIPHENYLTHIAZOLE is used as an antitumor agent, targeting cancer cells and potentially contributing to the development of novel cancer treatments.

Upstream product

• 70422-15-0 Dithiobenzoesaeure-phenacylester 
• 7257-94-5 1-phenyl-2-(p-tolylsulfonyloxy)ethanone 
• 2227-79-4 benzenecarbothioamide 
• 288-47-1 1,3-thiazole 
• 70-11-1 α-bromoacetophenone 
• 108-86-1 bromobenzene 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 98-80-6 phenylboronic acid 
• 53715-67-6 5-bromo-2-phenyl-1,3-thiazole 
• 960-16-7 tributylphenylstannane 
• 141305-40-0 4-bromo-2-phenylthiazole 
• 1225053-33-7 2-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole2 
• 1826-11-5 2-phenylthiazole 
• 100-41-4 ethylbenzene 

Downstream Products

• 3920-15-8 3,5-diphenylisothiazole 
• 2521-25-7 4-(4-nitrophenyl)-2-phenylthiazole 
• 2104-11-2 2,4,5-triphenylthiazole 
• 951000-48-9 5-fluoro-2,4-diphenylthiazole 
• 25021-48-1 4-(2-phenyl-thiazol-4-yl)-aniline 
• 25020-71-7 1,3-bis-[4-(2-phenyl-thiazol-4-yl)-phenyl]-thiourea 
• 130161-21-6 (2,4-Diphenyl-thiazol-5-yl)-phenyl-acetonitrile 
• 143031-94-1 2,4-diphenyl-α-phenylsulfonyl-5-thiazoleacetonitrile 
• 130161-16-9 5-chloro-2,4-diphenylthiazole 
• 35342-50-8 5-bromo-2,4-diphenylthiazole 
• 125509-51-5 2,4-diphenylthiazole-DDQ 
• 129819-12-1 (Z)-N-(1,2-diphenylvinyl)-1,1-diphenylmethanimine 
• 129819-14-3 (E)-1-phenyl-N-((Z)-1-phenylprop-1-en-1-yl)ethan-1-imine 
• 18665-29-7 2,4-diphenylthiazole-TCNE 

Relevant articles and documents

Efficient conversion of ketones to α-tosyloxyketones with m-chloroperbenzoic acid and p-toluenesulfonic acid in the presence of catalytic amount of IL-supported PhI in [emim]OTs

Various ketones were smoothly converted into the corresponding α-tosyloxyketones with MCPBA and p-toluenesulfonic acid in the presence of a catalytic amount of ionic-liquid (IL)-supported PhI in room temperature ionic liquid, [emim]OTs. Moreover, the pres

Environmentally benign preparation of heteroaromatics from ketones or alcohols, with macroporous polystyrenesulfonic acid and (diacetoxyiodo)benzene, followed by thioamide, amidine, and 2-aminopyridine

An operationally simple, efficient, and environmentally benign preparation of heteroaromatics such as thiazoles, imidazoles, and imidazo[1,2-a]pyridines from the reactions of a polymer-supported [hydroxy(sulfonyloxy)iodo]benzene (2) with ketones or alcohols, followed by treatment with thioamides, benzamidine, and 2-aminopyridine, respectively, in the presence of potassium carbonate were successfully carried out.

Preparation method of 2, 4-disubstituted thiazole compound

The invention discloses a preparation method of a 2, 4-disubstituted thiazole compound. The method comprises the following steps: carrying out heating reflux reaction on substituted carboxylic acid inthionyl chloride to obtain yellow transparent liquid, and adding dichloromethane to dilute for later use; in an ice bath, slowly dropwise adding the substituted acyl chloride solution into ammonia water while stirring, stirring at room temperature to separate out a white solid, and after the reaction is finished, carrying out suction filtration, washing and drying to obtain substituted amide; carrying out reflux on substituted amide and Lawesson in tetrahydrofuran, carrying out rotary evaporation to remove the solvent after the reaction is finished, and carrying out column purification on thecrude product to obtain substituted sulfamide. The preparation method comprises the following steps: putting substituted sulfamide, ethanol, triethylamine and an alpha-bromocarbonyl compound into a pressure reaction tank, putting the pressure reaction tank into an annular focusing single-mode microwave synthesizer for irradiation, and cooling with compressed air to obtain a target compound. Basedon microwave synthesis, the invention has the advantages of short reaction time, high yield, high heating speed, environment friendliness and the like, and provides a microwave synthesis method of a2, 4-disubstituted thiazole compound.

Br?nsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source

A Br?nsted acid-promoted sulfuration/annulation reaction for the one-pot synthesis of bis-substituted thiazoles from benzylamines, acetophenones, and sulfur powder has been developed. One C-N bond and multi C-S bonds were selectively formed in one pot. The choice of the Br?nsted acid was the key to the high efficiency of this transformation under metal-free conditions.