20059-73-8Relevant articles and documents
Overcoming inaccessibility of fluorinated imines-synthesis of functionalized amines from readily available fluoroacetamides
Czerwiński, Pawe? J.,Furman, Bart?omiej
, p. 9436 - 9439 (2019/08/15)
Although imines are convenient substrates for the synthesis of functionalized amines, they may be hard to obtain, as in the case of fluorinated imines. To aid in overcoming this issue, we propose a protocol of corresponding amine synthesis from simple fluoroacetic acid-derived amides using Schwartz's reagent.
Preparation method of 4-(2-dimethylaminoethoxy)benzylamine
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Paragraph 0038; 0039; 0040; 0041, (2017/07/19)
The invention provides a preparation method of 4-(2-dimethylaminoethoxy)benzylamine. The preparation method comprises the following steps: dissolving 4-(2-dimethylaminoethoxy)benzyl bromide and urotropin in a solvent and reacting; after reacting, recycling the solvent; hydrolyzing a reaction product under an acidic condition; and adding an alkali and neutralizing to obtain the 4-(2-dimethylaminoethoxy)benzylamine. According to the preparation method provided by the invention, the raw materials have low prices and are easy to obtain; industrialization of the process is easy to realize; and the final product has high purity.
Preparation method of itopride hydrochloride
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Paragraph 0007; 0015, (2017/01/12)
The invention relates to a preparation method of itopride hydrochloride. The preparation method includes: using 2-dimethylaminoethyl chloride hydrochloride and phenol as starting materials for reaction; subjecting the starting materials to etherification, chloromethylation, amino substitution, amidation and salifying to obtain itopride hydrochloride. Chloromethylation promoted by C/CHO is adopted, so that a step of imine reduction is omitted, solid residue generated by a reductant is eliminated, and reaction safety is improved; raw materials used in the method are low in price, sufficient in market supply and easy to purchase; reaction in each step is classic, and the preparation method is safe, easy to control and suitable for industrial production.