2158-03-4

Basic information

• Product Name: 1-CARBAMYLPIPERIDINE
• Synonyms: 1-CARBAMYLPIPERIDINE;1-PIPERIDINECARBOXAMIDE;PIPERIDINE-1-CARBOXAMIDE;TIMTEC-BB SBB004238;n,n-pentamethyleneurea
• CAS NO: 2158-03-4
• Molecular Formula: C₆H₁₂N₂O
• Molecular Weight: 128.17
• EINECS: 218-476-5
• Product Categories: API intermediates
• Mol File: 2158-03-4.mol
• Article Data: 30

Chemical Properties

• Melting Point: 104-106 °C(lit.)
• Boiling Point: 237.61°C (rough estimate)
• Flash Point: 91.2°C
• Appearance: /
• Density: 1.0754 (rough estimate)
• Vapor Pressure: 0.0783mmHg at 25°C
• Refractive Index: 1.4880 (estimate)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-CARBAMYLPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CARBAMYLPIPERIDINE(2158-03-4)
• EPA Substance Registry System: 1-CARBAMYLPIPERIDINE(2158-03-4)

Safety Data

• WGK Germany: 3
• RTECS: TM5975700
• Hazardous Substances Data: 2158-03-4(Hazardous Substances Data)

Usage

General Description

1-Carbamylpiperidine is a chemical compound with the molecular formula C7H14N2O. It is a derivative of piperidine, which is a cyclic amine commonly used in the synthesis of pharmaceuticals and agrochemicals. 1-Carbamylpiperidine is used as an intermediate in the manufacturing of various drugs, such as antihistamines and antipsychotics. It is also utilized in the production of certain pesticides and other agricultural chemicals. This chemical is a white to pale yellow solid at room temperature and is typically handled and stored under controlled conditions due to its potential hazards.

InChI:InChI=1/C6H12N2O/c7-6(9)8-4-2-1-3-5-8/h1-5H2,(H2,7,9)

Upstream product

• 110-89-4 piperidine 
• 2597-54-8 ethyl acetylcarbamate 
• 143-33-9 sodium cyanide 
• 29044-24-4 N-(N-hydroxyamidino)piperidine 
• 29044-24-4 N-(N-hydroxyamidino)piperidine 
• 39531-35-6 N-benzyl-N',N'-(1,5-pentamethylenediyl)urea 
• 2937-50-0 Allyl chloroformate 
• 79-06-1 2-propenamide 
• 590-28-3 potassium cyanate 
• 6091-44-7 piperidine hydrochloride 
• 39546-32-2 4-carboxamidopiperidine 
• 89483-79-4 2-(p toluene sulphonyloxymethyl) 6-methyl 2,3-dihydro [4H] 1,4-benzodioxin 
• 2488-15-5 N-tert-butoxycarbonyl-L-methionine 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 101275-75-6 (piperidine-1-carbonyl)-(3,4,5-trimethoxy-benzoyl)-amine 
• 87448-66-6 2,3,4,5,6-Pentachloro-phenol; compound with piperidine-1-carboxylic acid amide 
• 627-12-3 1-propyl carbamate 
• 6091-49-2 piperidinium picrate 
• 87448-65-5 Picric acid; compound with piperidine-1-carboxylic acid amide 
• 104417-81-4 N-Benzoyl-N-(piperidine-1-carbonyl)-benzamide 
• 87448-63-3 Piperidine-1-carboxylic acid amide; compound with benzene-1,4-diol 
• 1530-87-6 1-piperidinylcarbonnitrile 
• 2213-43-6 1-Aminopiperidine 
• 1255650-67-9 N-(2-fluorobenzoyl)piperidine-1-carboxamide 
• 1255650-62-4 N-(4-cyanobenzoyl)piperidine-1-carboxamide 
• 1255650-79-3 6-cyano-N-(piperidine-1-carbonyl)nicotinamide 
• 5499-34-3 N-Benzoyl-N',N'-pentamethylen-harnstoff 
• 534560-89-9 N-(4-methoxybenzoyl)piperidine-1-carboxamide 

Relevant articles and documents

Sequential base-promoted annulation/palladium-catalyzed domino 1,5-enyne arylation and vinylation of α-propargylaminohydrazones

Stereoselective dominos: Cascade reactions of easily accessible α-propargylaminohydrazones 1 represent a simple and efficient method for the preparation of pyrazolones 3.

Regioselective Formal [3+2] Cycloadditions of Urea Substrates with Activated and Unactivated Olefins for Intermolecular Olefin Aminooxygenation

A new class of intermolecular olefin aminooxygenation reaction is described. This reaction utilizes the classic halonium intermediate as a regio- and stereochemical template to accomplish the selective oxyamination of both activated and unactivated alkenes. Notably, urea chemical feedstock can be directly introduced as the N and O source and a simple iodide salt can be utilized as the catalyst. This formal [3+2] cycloaddition process provides a highly modular entry to a range of useful heterocyclic products with excellent selectivity and functional-group tolerance.

A practically simple, catalyst free and scalable synthesis of: N -substituted ureas in water

A practically simple, mild and efficient method is developed for the synthesis of N-substituted ureas by nucleophilic addition of amines to potassium isocyanate in water without organic co-solvent. Using this methodology, a variety of N-substituted ureas (mono-, di- and cyclic-) were synthesized in good to excellent yields with high chemical purity by applying simple filtration or routine extraction procedures avoiding silica gel purification. The developed methodology was also found to be suitable for gram scale synthesis of molecules having commercial application in large volumes. The identified reaction conditions were found to promote a unique substrate selectivity from a mixture of two amines.