23126-82-1Relevant articles and documents
Palladium-catalyzed amination of chloro-substituted 5-nitropyrimidines with amines
Liu, Meng-Meng,Mei, Qiong,Zhang, Yi-Xiao,Bai, Peng,Guo, Xiang-Hai
, p. 583 - 587 (2017/06/19)
A concise and efficient approach was developed for the synthesis of mono-substituted and di-substituted pyrimidines products via palladium-catalyzed amination of chloro-substituted 5-nitropyrimidines and amines. This synthetic methodology can produce vari
Novel 8-arylated purines as inhibitors of glycogen synthase kinase
Ibrahim, Nada,Mouawad, Liliane,Legraverend, Michel
scheme or table, p. 3389 - 3393 (2010/08/06)
A series of 8-arylated purine derivatives bearing either an aniline or an alkyl amide at position 6 were found to inhibit glycogen synthase kinase-3,with good selectivity over ten kinases. Molecular modeling studies indicated that the most active compounds (8a and 8e),adopt a planar conformation,close to the shape of AMPPNP in the crystal structure of GSK-3. These compounds are stabilized by hydrophobic contacts between the 8-aromatic group and the protein adenine pocket and by electrostatic contacts.
Purines, Pyrimidines, and Imidazoles. Part 61. Reaction of 6-Alkylamino-4-chloro-5-nitropyrimidines with Diethyl Malonate, Ethyl Cyanoacetate, and Ethyl Acetoacetate and some derived Pyrrolopyrimidines related to the Cytokinins
Gregson, Stephen,Shaw, Gordon
, p. 187 - 190 (2007/10/02)
Reaction of 4-chloro-6-methylamino-5-nitropyrimidine (3d) with diethyl malonate and sodium hydroxide afforded diethyl 6-methylamino-5-nitropyrimidin-4-ylmalonate which was reduced to diethyl 5-amino-6-methylaminopyrimidin-4-ylmalonate and this, with sodiu