231610-93-8Relevant articles and documents
Two-fragment α-adrenolytics 4. Synthesis of phosphorylated derivatives of 2-aryloxyethylamines and N-phenylpiperazine
Reznik,Akamsin,Galyametdinova
, p. 125 - 129 (2007/10/03)
The reactions of 3-chloropropylphosphonates, 3-chloropropylthiophosphonates, or 3-chloropropylphosphinates with 2-aryloxyethylamines or N-phenylpiperazine afford the corresponding 3-(2-aryloxyethylamino)propylphosphonates and -phosphinates or 3-(4-phenylpiperazin-1-yl)propylphosphonates and -phosphinates. The compounds obtained exhibit α-adrenolytic and hypotensive activities, the latter being found to depend on the substituents at the P atom.
