23585-49-1

Basic information

• Product Name: (1H-PYRAZOL-3-YL)METHANOL
• Synonyms: 3-(HYDROXYMETHYL)PYRAZOLE;1H-PYRAZOLE-3-METHANOL;(1H-PYRAZOL-3-YL)METHANOL;1H-pyarzole-3-methanol;3-HyroxyMethyl-1H-pyrazole;3-HyroxyMethyl-1H-pyrazol...;23585-49-1
• CAS NO: 23585-49-1
• Molecular Formula: C₄H₆N₂O
• Molecular Weight: 98.10324
• Product Categories: pharmacetical
• Mol File: 23585-49-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 184-185 °C
• Boiling Point: 326.8°Cat760mmHg
• Flash Point: 151.5°C
• Appearance: /
• Density: 1.311g/cm³
• Vapor Pressure: 8.54E-05mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: 2-8°C
• PKA: 13.59±0.10(Predicted)
• CAS DataBase Reference: (1H-PYRAZOL-3-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (1H-PYRAZOL-3-YL)METHANOL(23585-49-1)
• EPA Substance Registry System: (1H-PYRAZOL-3-YL)METHANOL(23585-49-1)

Safety Data

• Hazardous Substances Data: 23585-49-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless Liquid

InChI:InChI=1/C4H6N2O/c7-3-4-1-2-5-6-4/h1-2,7H,3H2,(H,5,6)

Upstream product

• 64-17-5 ethanol 
• 99805-29-5 4-tetrahydropyran-2-yloxy-but-2-ynal-diethylacetal 
• 1621-91-6 1H-pyrazole-3-carboxylic acid 
• 107-19-7 propargyl alcohol 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 15366-34-4 methyl 1H-pyrazole 3-carboxylate 
• 122609-00-1 1⁽²⁾H-pyrazole-3-carboxylic acid butyl ester 
• 5932-27-4 ethyl 1H-pyrazole-3-carboxylate 
• 18350-44-2 4,4-diethoxy-but-2-yn-1-ol 
• 186581-53-3 diazomethane 
• 60-29-7 diethyl ether 

Downstream Products

• 869558-95-2 (1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-3-yl)methanol 
• 3920-50-1 3-formylpyrazole 
• 1562342-97-5 (1-(3-bromo-4-methoxyphenyl)-1H-pyrazol-3-yl)methanol 
• 1191923-32-6 C₂₃H₂₇N₅O₄ 
• 1202644-77-6 1-(7-(5-(hydroxymethyl)-1H-pyrazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(5-(pyridin-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethane-1,2-dione 
• 1202644-78-7 1-(7-(3-(hydroxymethyl)-1H-pyrazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(5-(pyridin-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethane-1,2-dione 
• 102846-12-8 3-bromomethylpyrazole 
• 99939-07-8 1-Amino-1H-pyrazol-3-methanol 
• 23784-89-6 3-(chloromethyl)-1H-pyrazole 

Relevant articles and documents

SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1

The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): (Iar) wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.