26586-02-7Relevant articles and documents
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Pattenden,G. et al.
, p. 235 - 241 (1970)
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Preparation method of 2-methyl-4-acetoxy-2-butenal with thermal stability
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Paragraph 0058-0077, (2021/11/06)
The invention discloses a preparation method of 2-methyl-4-acetoxy-2-butenal with thermal stability, which comprises the following steps: (1) carrying out gas-solid-liquid three-phase hydroisomerization reaction on 2-methylene-4-acetoxybutyraldehyde and a solvent under the action of a catalyst to generate 2-methyl-4-acetoxy-2-butenal; (2) after the reaction reaches a specified conversion rate, terminating the reaction, conducting cooling and filtering out the catalyst; and (3) rectifying and separating the solvent, hydrogenation by-products and unreacted raw materials in the system to obtain the product 2-methyl-4-acetoxy-2-butenal. In the step (1), active hydrogen in the used solvent is controlled to be less than or equal to 100mgKOH/kg in terms of hydroxyl value content. The 2-methyl-4-acetoxy-2-butenal provided by the invention is good in thermal stability, low in loss rate in a rectification separation process and low in cis-isomer content, and can better meet downstream requirements.
Synthesis of fluorescently tagged isoprenoid bisphosphonates that inhibit protein geranylgeranylation
Maalouf, Mona A.,Wiemer, Andrew J.,Kuder, Craig H.,Hohl, Raymond J.,Wiemer, David F.
, p. 1959 - 1966 (2007/10/03)
Geminal bisphosphonates can be used for a variety of purposes in human disease including reduction of bone resorption in osteoporosis, treatment of fractures associated with malignancies of the prostate, breast, and lung, and direct anticancer activity ag
Synthesis of (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate, a key intermediate in the biosynthesis of isoprenoids
Ward, Jane L.,Beale, Michael H.
, p. 710 - 712 (2007/10/03)
The synthesis of (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate (HMBPP) was described by regioselective hydroxylation and diphosphorylation of dimethylallyl alcohol. The synthesis started from commercially available 3-methylbut-2-en-1-ol. The 1-alcohol function of starting material was converted to the acetate by treatment with pyridine acetic anhydride. Selective allylic hydroxylation was achieved using selenium dioxide and tert-butyl hydro-peroxide.