28957-08-6

Basic information

• Product Name: lasiokaurin
• Synonyms: (14R)-1α-Acetoxy-7α,20-epoxy-6β,7,14-trihydroxykaur-16-en-15-one;NSC 250683;Oridonin 1-acetate;6,7,14-trihydroxy-15-oxo-7,20-epoxykaur-16-en-1-yl acetate;Lasiodin
• CAS NO: 28957-08-6
• Molecular Formula: C₂₂H₃₀O₇
• Molecular Weight: 406.472
• Product Categories: Miscellaneous Natural Products
• Mol File: 28957-08-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 238-239℃
• Boiling Point: 588°C at 760 mmHg
• Flash Point: 203.8°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 2.82E-16mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: lasiokaurin(CAS DataBase Reference)
• NIST Chemistry Reference: lasiokaurin(28957-08-6)
• EPA Substance Registry System: lasiokaurin(28957-08-6)

Safety Data

• Hazardous Substances Data: 28957-08-6(Hazardous Substances Data)

Usage

Definition

ChEBI: A natural product found in Isodon adenolomus.

InChI:InChI=1/C22H30O7/c1-10-12-5-6-13-20-9-28-22(27,21(13,16(10)24)17(12)25)18(26)15(20)19(3,4)8-7-14(20)29-11(2)23/h12-15,17-18,25-27H,1,5-9H2,2-4H3

Upstream product

• 28957-04-2 oridonin 
• 108-24-7 acetic anhydride 
• 331282-95-2 ent-1α-O-acetyl-6β-hydroxy-7,14-isopropylidene ketal-15-oxo-7,20-epoxy-16-kaurene 
• 331282-94-1 ent-1α,6β-dihydroxy-7,14-isopropylidene ketal-15-oxo-7,20-epoxy-16-kaurene 
• 28957-07-5 1,14-O,O-diacetyl oridonin 

Downstream Products

• 1422272-59-0 ent-1α-O-acetyl-14β-O-(o-chlorobenzoyl)-6,7,15-trioxo-7,20-epoxy-6,7-seco-16-kaurene 
• 1422272-58-9 ent-1α-O-acetyl-14β-O-(p-chlorobenzoyl)-6,7,15-trioxo-7,20-epoxy-6,7-seco-16-kaurene 
• 1284213-90-6 ent-1α-O-acetyl-14β-O-(p-nitrobenzoyl)-6,7,15-trioxo-7,20-epoxy-6,7-seco-16-kaurene 
• 1422272-57-8 ent-1α-O-acetyl-14β-O-(p-trifluoromethylbenzoyl)-6,7,15-trioxo-7,20-epoxy-6,7-seco-16-kaurene 
• 1422272-56-7 ent-1α-O-acetyl-14β-O-(p-methoxybenzoyl)-6,7,15-trioxo-7,20-epoxy-6,7-seco-16-kaurene 
• 1422272-55-6 ent-1α-O-acetyl-14β-O-(p-methylbenzoyl)-6,7,15-trioxo-7,20-epoxy-6,7-seco-16-kaurene 
• 1284213-96-2 ent-1α-O-acetyl-14β-O-benzoyl-6,7,15-trioxo-7,20-epoxy-6,7-seco-16-kaurene 

Relevant articles and documents

Oridonin derivatives as potential anticancer drug candidates triggering apoptosis through mitochondrial pathway in the liver cancer cells

The biological function of the natural ent-kaurene diterpenoid isolated from genus Isodon, oridonin, has been intensively studied. However, its mechanism studies and clinical applications were hampered by its moderate biological activities. In order to en

Structural modification of oridonin: Via DAST induced rearrangement

A simple and efficient protocol was developed for the syntheses of oridonin analogues, i.e. 6,20-epoxy ent-kaurane diterpenoid analogues from oridonin via diethylaminosulfur trifluoride (DAST) promoted rearrangement, most of which exhibited superior anticancer activities compared with their precursor.

Spirolactone type diterpene spliced hydrogen sulfide donor derivatives as well as preparation method and application thereof

The invention relates to the field of natural medicines and medicinal chemistry, and relates to spirolactone diterpene spliced hydrogen sulfide donor derivatives as well as a preparation method and application thereof. The invention particularly relates to the preparation method of a series of spirolactone type kaurane diterpene hydrogen sulfide donor derivatives with anti-tumor activity and the application of the derivatives in preparation of anti-tumor drugs. The spirolactone type diterpene hydrogen sulfide donor derivatives and the pharmaceutically acceptable salts thereof are represented by a general formula I or II, wherein R is as described in the claims and the specification.