352458-37-8 Usage
Description
ABT-492 MegluMine, also known as Delafloxacin Meglumine, is a broad-spectrum anionic fluoroquinolone antibiotic with a distinct chemical structure that increases its potency in acidic environments. It was approved by the U.S. Food and Drug Administration (FDA) in June 2017 for the treatment of acute bacterial skin and skin structure infections. Delafloxacin Meglumine works by inhibiting DNA replication and repair, targeting DNA gyrase and topoisomerase IV.
Uses
Used in Pharmaceutical Industry:
ABT-492 MegluMine is used as an antibiotic for the treatment of acute bacterial skin and skin structure infections. It is effective against various bacteria, including methicillin-resistant Staphylococcus aureus, Streptococci, Enterobacteriaceae, and Pseudomonas aeruginosa. The drug is administered via both oral and parenteral routes, providing flexibility in treatment options.
Additionally, due to its potent activity against a wide range of bacteria, ABT-492 MegluMine may also be considered for use in other applications within the pharmaceutical industry, such as the development of new treatments for bacterial infections in different parts of the body or in combination with other drugs to enhance their efficacy. However, further research and clinical trials would be necessary to establish the safety and effectiveness of such applications.
Physical Form
Solid
Biological Activity
Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine is a broad spectrum fluoroquinolone antibiotic. Delafloxacin has a wide range of activity against drug-resistant Staphylococcus aureus, Streptococcus pneumoniae and Klebsiella pneumoniae.
Check Digit Verification of cas no
The CAS Registry Mumber 352458-37-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,2,4,5 and 8 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 352458-37:
(8*3)+(7*5)+(6*2)+(5*4)+(4*5)+(3*8)+(2*3)+(1*7)=148
148 % 10 = 8
So 352458-37-8 is a valid CAS Registry Number.
352458-37-8Relevant articles and documents
Refining method of ciprofloxacin and meglumine hydrochloride thereof
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, (2021/10/27)
The invention provides a preparation process of ciprofloxacin and meglumine thereof. The intermediate product DLSX07 is stirred at Branson ° C. 20% minutes and then sonicated until the solution is cloudy, stirred at room temperature for a period 30s, stirred at room temperature 3h, cooled and slowly added to distilled water, and filtered through suction filtration and filter cake vacuum drying to obtain a pale yellow powder, and 4% the KOH mixture is subjected to ultrasonic treatment 40 - 50 °C. 1. The process is performed by stirring 5h. NCS .t. The solution is cloudy. LC-MS / MS detection powder is deltafloxacin, distilled water is added, and meglumine is mixed to obtain a deltafloxacin meglumine salt. By optimizing the preparation process, the use of the organic solvent is reduced, the reaction time is shortened, and the ice bath and the addition of the interface carrier material contribute to the improvement of the yield.
Preparation method of Delafloxacin and intermediates thereof
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, (2018/08/04)
The invention relates to a preparation method of Delafloxacin and intermediates thereof. The method comprises the following steps: firstly, taking 3-chloro-2,4,5-fluorobenzoic acid (compound 1) as a raw material and reacting the raw material with thionyl
Preparation method of high-purity delafloxacin meglumine salt
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, (2017/04/27)
The invention relates to a method for refining a delafloxacin intermediate compound shown in a formula I. The method comprises the following steps: dissolving the compound in the formula I in a good solvent, mixing the compound with a poor solvent, heatin