35807-85-3 Usage
Description
Tauroursodeoxycholic Acid Sodium Salt, also known as TUDCA, is a bile acid derived from the conjugation of taurine with ursodeoxycholic acid. It is an off-white solid with unique properties that make it a valuable compound in various scientific and medical applications.
Uses
Used in Pharmaceutical Industry:
Tauroursodeoxycholic Acid Sodium Salt is used as a therapeutic agent for the treatment of various liver diseases. It has been shown to have hepatoprotective effects, reducing liver injury and promoting liver regeneration.
Used in Biological Research:
TAUROURSODEOXYCHOLIC ACID SODIUM SALT is used as a research tool for studying the inhibition of alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption by glycyrrhizin and glycyrrhetinic acid. It helps in understanding the underlying mechanisms of liver diseases and the potential therapeutic interventions.
Used in Cancer Research:
Tauroursodeoxycholic Acid Sodium Salt is used as an inhibitor in cancer research, specifically in the study of human cholangiocarcinoma growth. It has been shown to inhibit cancer cell growth via Ca2+-, PKC-, and MAPK-dependent pathways, providing insights into the development of novel cancer treatments.
Used in Endocrinology Research:
TAUROURSODEOXYCHOLIC ACID SODIUM SALT is used as a research compound to assess the involvement of endoplasmic reticulum (ER) stress in palmitic acid upregulation and to investigate its effect on Estradiol-17β-D-glucuronide (E-17G) induced cholestasis in female rats. This helps in understanding the role of bile acids in endocrine regulation and their potential implications in metabolic disorders.
Used in Drug Delivery Systems:
Although not explicitly mentioned in the provided materials, Tauroursodeoxycholic Acid Sodium Salt could potentially be used in drug delivery systems due to its ability to interact with lipids and membrane-bound proteins. This property may facilitate the development of novel drug delivery platforms for improved bioavailability and targeted drug delivery.
Check Digit Verification of cas no
The CAS Registry Mumber 35807-85-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,8,0 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 35807-85:
(7*3)+(6*5)+(5*8)+(4*0)+(3*7)+(2*8)+(1*5)=133
133 % 10 = 3
So 35807-85-3 is a valid CAS Registry Number.
35807-85-3Relevant articles and documents
Co-immobilised 7α- and 7β-HSDH as recyclable biocatalyst: high-performance production of TUDCA from waste chicken bile
Ji, Qingzhi,Wang, Bochu,Li, Chou,Hao, Jinglan,Feng, Wenjing
, p. 34192 - 34201 (2018)
Chicken gallbladder has long been considered to be worthless and discarded as waste. The main composition of chicken bile is taurochenodeoxycholic acid (TCDCA), which is the isomeride of tauroursodeoxycholic acid (TUDCA). TUDCA has been effectively used for treatment of many diseases. In this paper, 7α- and 7β-hydroxysteroid dehydrogenases (HSDH) were co-immobilised on modified chitosan microspheres, and used as recyclable biocatalyst for the catalysis of chicken bile. The catalytic reaction reached equilibrium within 4 h compared with 1 h using TCDCA as substrate. After four continuous batch reactions, the conversion of TCDCA was lower than 40% and TUDCA yield was about 15% for the catalysis of chicken bile. TUDCA yield was approximately 62% after equilibrium and the content of TUDCA in reaction product was as high as 33.16%. Furthermore, the experiments showed that activity of enzymes were significantly inhibited by bilirubin, Cu2+ and Ca2+ in complex substrate. The research described not only widens the utilization of chicken bile, but also provides a clean way for the preparation of TUDCA.
Process for the preparation of tauroursodesoxycholic acid
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Page/Page column 4, (2008/12/04)
The present invention relates to a novel method for preparing tauroursodeoxycholic acid which comprises a step of selective precipitation of the impurities present in the suspension obtained from the reaction of an aqueous solution of sodium taurinate with an acetonic solution of a mixed anhydride of ursodeoxycholic acid with an alkyl chloroformate.