36623-66-2Relevant articles and documents
A Catalytic Oxidative Quinone Heterofunctionalization Method: Synthesis of Strongylophorine-26
Yu, Wanwan,Hjerrild, Per,Jacobsen, Kristian M.,Tobiesen, Henriette N.,Clemmensen, Line,Poulsen, Thomas B.
supporting information, p. 9805 - 9809 (2018/07/31)
The preparation of heteroatom-substituted p-quinones is ideally performed by direct addition of a nucleophile followed by in situ reoxidation. Albeit an appealing strategy, the reactivity of the p-quinone moiety is not easily tamed and no broadly applicable method for heteroatom functionalization exists. Shown herein is that Co(OAc)2 and Mn(OAc)3?2 H2O act as powerful catalysts for oxidative p-quinone functionalization with a collection of O, N, and S nucleophiles, using oxygen as the terminal oxidant. Preliminary mechanistic observations and the first synthesis of the cytotoxic natural product strongylophorine-26 is presented.
CHEMICAL INHIBITOR OF P53-SNAIL BINDING AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER DISEASE CONTAINING SAME AS ITS ACTIVE INGREDIENT
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Page/Page column 9, (2012/02/01)
Provided are compounds for inhibiting Snail-p53 binding and therapeutic agents for cancer including the compounds as an effective component. The Snail-p53 binding inhibitors induce expression of p53 in K-Ras mutant cell lines, thereby enabling effective t
Preparation of new dialkyl benzene-, biphenyl-, and naphthalene- bis(α-oxoethanedithioates)
Voss, Jurgen,Sarafidis, Abraam,Sawluk, Andrzej,Schmidt, Gunther,Adiwidjaja, Gunadi
experimental part, p. 2249 - 2276 (2011/01/12)
Novel arene-bis- and -tris(-oxoethanedithioate) esters of the benzene, the biphenyl, and, in particular, the naphthalene series were prepared by reaction of the corresponding diazoacetyl or bromoacetyl derivatives with elemental sulfur in the presence of triethylamine in dry DMF, and subsequent direct alkylation of the produced dithiocarboxylate anions. The thiolation reaction of the diazoketones was significantly promoted by the addition of anhydrous calcium chloride (calcium chloride-activated thiolation, or CAT). Certain carbonyl-activated methylene and methyl compounds exhibiting no bromo or diazo substituents could be also transformed into dithioesters by the CAT reaction. The structure of three dithioesters was corroborated by X-ray structural analyses. Copyright Taylor & Francis Group, LLC.
