369-34-6 Usage
Description
3,4-Difluoronitrobenzene is a clear yellow liquid that has been the subject of experimental and computational thermochemical studies. It is an organic compound with the molecular formula C6H3F2NO2, featuring two fluorine atoms and a nitro group attached to a benzene ring.
Uses
Used in Pharmaceutical Industry:
3,4-Difluoronitrobenzene is used as a synthetic intermediate for the preparation of various pharmaceutical compounds, such as xanthones and acridones. These compounds have potential applications in the development of new drugs due to their diverse chemical properties and biological activities.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3,4-difluoronitrobenzene serves as a valuable building block for the creation of a wide range of fluorinated organic compounds. The presence of fluorine atoms in the molecule can significantly influence the reactivity, stability, and biological properties of the resulting compounds, making it a useful precursor in the synthesis of various specialty chemicals and materials.
Used in Research and Development:
3,4-Difluoronitrobenzene is also utilized in research and development settings, where its unique chemical properties and reactivity are explored for potential applications in new technologies and innovations. The experimental and computational thermochemical studies conducted on this compound contribute to the understanding of its properties and behavior, which can be applied to design more efficient synthetic routes and novel applications in various industries.
Synthesis Reference(s)
The Journal of Organic Chemistry, 63, p. 8448, 1998 DOI: 10.1021/jo981557o
Check Digit Verification of cas no
The CAS Registry Mumber 369-34-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,6 and 9 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 369-34:
(5*3)+(4*6)+(3*9)+(2*3)+(1*4)=76
76 % 10 = 6
So 369-34-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H5FN2O2/c7-5-2-1-4(9(10)11)3-6(5)8/h1-3H,8H2
369-34-6Relevant articles and documents
Method for pipeline continuous fluorination with fluorine salt as fluorine source
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Paragraph 0056-0061; 0094-0096, (2021/10/27)
The method comprises the following steps: dissolving a fluorine salt in an aqueous polar aprotic solvent as reaction liquid A, dissolving an aryl (heterocyclic) chloride in a polar aprotic solvent as reaction liquid B, and reacting a polar aprotic solvent in the reaction liquid A with a polar aprotic solvent of the reaction liquid B. The reaction medium consisting of the preheated reaction liquid A and the preheated reaction liquid B enters the reaction coil for a fluorination reaction, and the resulting product from the reaction coil is subjected to post-treatment to obtain the product. The method has the characteristics of no need of adding a phase transfer catalyst, continuous production, low production cost and the like.
Method for synthesizing 3-fluoro-4-(4-morpholinyl)aniline by using micro-channel reactor
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Paragraph 0027; 008-0059; 0067; 0075-0077; 0087, (2017/08/27)
The invention provides a method for synthesizing 3-fluoro-4-(4-morpholinyl)aniline by using a micro-channel reactor. The micro-channel reactor comprises a preheating module group composed of one or more parallely-connected preheating modules and a reactio
Copper-catalyzed hydrodefluorination of fluoroarenes by copper hydride intermediates
Lv, Hongbin,Cai, Yuan-Bo,Zhang, Jun-Long
supporting information, p. 3203 - 3207 (2013/04/23)
Breaking bad: Efficient copper-catalyzed C-F bond activation has been achieved by replacing fluorine with hydrogen. A copper hydride is proposed as the active intermediate, which proceeds through a nucleophilic attack on the fluorocarbon, as determined by experimental and theoretical results (see structure; C gray, H white, Cu light red, F light blue; distances in ?).