37595-74-7 Usage
Description
N-Phenyl-bis(trifluoromethanesulfonimide) is a white to off-white crystalline powder with unique chemical properties that make it a versatile compound in various applications across different industries.
Uses
1. Enantioselective Synthesis:
N-Phenyl-bis(trifluoromethanesulfonimide) is used as a reagent in the enantioselective synthesis of β-amino acids via the Mannich reaction. This application is particularly relevant in the pharmaceutical industry, where the production of chiral molecules with specific configurations is crucial for the development of effective drugs.
2. Pharmaceutical Applications:
In the pharmaceutical industry, N-Phenyl-bis(trifluoromethanesulfonimide) is used as a key intermediate in the synthesis of sphingosine 1-phosphate-1 receptor agonists. These agonists have potential therapeutic applications in treating various diseases and conditions.
3. Carbon Nanotubes:
N-Phenyl-bis(trifluoromethanesulfonimide) acts as a transparent, strong electron-withdrawing p-type dopant in carbon nanotubes. This application is significant in the field of materials science and nanotechnology, where the development of advanced materials with improved properties is a continuous pursuit.
4. Synthesis of Amphoteric Alpha-Boryl Aldehydes:
N-Phenyl-bis(trifluoromethanesulfonimide) is used as a reactant in the synthesis of amphoteric alpha-boryl aldehydes, which are valuable building blocks in organic chemistry and can be used to construct a wide range of complex molecules.
5. Enantioselective Synthesis of Core Ring Skeleton of Leucosceptroids A-D:
N-Phenyl-bis(trifluoromethanesulfonimide) is employed in the enantioselective synthesis of the core ring skeleton of leucosceptroids A-D, which are natural products with potential biological activities.
6. Stereoselective Synthesis of Monoamine Reuptake Inhibitor NS9544 Acetate:
N-Phenyl-bis(trifluoromethanesulfonimide) is used in the stereoselective synthesis of monoamine reuptake inhibitor NS9544 acetate, a molecule with potential applications in the treatment of neurological and psychiatric disorders.
7. Stereoselective Sulfoxidation:
N-Phenyl-bis(trifluoromethanesulfonimide) is also utilized in stereoselective sulfoxidation reactions, which are important for the preparation of chiral sulfoxides and their derivatives, finding applications in various fields, including pharmaceuticals and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 37595-74-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,5,9 and 5 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 37595-74:
(7*3)+(6*7)+(5*5)+(4*9)+(3*5)+(2*7)+(1*4)=157
157 % 10 = 7
So 37595-74-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H5F6NO4S2/c9-7(10,11)20(16,17)15(6-4-2-1-3-5-6)21(18,19)8(12,13)14/h1-5H
37595-74-7Relevant articles and documents
Preparation method of N-phenyl bis (trifluoromethanesulfonyl) imine
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Paragraph 0026-0052, (2022/01/12)
The invention relates to a preparation method of N-phenyl bis (trifluoromethanesulfonyl) imine, and belongs to the technical field of chemical engineering. The method comprises the following steps: dissolving trifluoromethanesulfonic acid and organic alkali in an organic solvent, and adding HATU for reaction; the reaction temperature is greater than or equal to 15 DEG C, and the organic solvent is not boiled; after the reaction is finished, a reaction solution containing trifluoromethanesulfonic acid active ester is obtained; adding aniline into the reaction liquid, and reacting at 25 +/-5 DEG C for 6-12 hours; and after the reaction is finished, removing the organic solvent to obtain a crude product containing the N-phenyl bis (trifluoromethanesulfonyl) imine, washing, and recrystallizing and purifying by using an alcohol solvent with 1-3 carbon atoms to obtain the N-phenyl bis (trifluoromethanesulfonyl) imine. The N-phenyl bis (trifluoromethanesulfonyl) imine with high purity and high yield can be prepared by the method, the reaction condition is mild, the utilization rate of raw materials is high, and the method is green and environment-friendly.
Meta Selective C-H Borylation of Sterically Biased and Unbiased Substrates Directed by Electrostatic Interaction
Chaturvedi, Jagriti,Haldar, Chabush,Bisht, Ranjana,Pandey, Gajanan,Chattopadhyay, Buddhadeb
supporting information, p. 7604 - 7611 (2021/05/26)
An electrostatically directed meta borylation of sterically biased and unbiased substrates is described. The borylation follows an electrostatic interaction between the partially positive and negative charges between the ligand and substrate. With this strategy, it has been demonstrated that a wide number of challenging substrates, especially 4-substituted substrates, can selectively be borylated at the meta position. Moreover, unsubstituted substrates also displayed excellent meta selectivity. The reaction employs a bench-stable ligand and proceeds at a milder temperature, precluding the need to synthesize a bulky and sophisticated ligand/template.
Method for preparing N-phenyl-bis (perfluoroalkyl sulfonyl) imide
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Paragraph 0025-0030, (2020/01/12)
The invention relates to a method for preparing N-phenyl-bis (perfluoroalkyl sulfonyl) imide, and belongs to the technical field of preparation of perfluoroalkyl sulfonylation reagents. According to the method, perfluoroalkyl sulfonyl fluoride and aniline are used as raw materials, and N-phenyl-bis (perfluoroalkyl sulfonyl) imide is prepared under the action of a catalyst. The method disclosed bythe invention is simple in process flow, mild in reaction, good in safety, low in cost, high in yield and high in purity.