38191-34-3Relevant articles and documents
HMOX1 inducers
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Page/Page column 122, (2020/09/18)
The present invention is related to compounds of structure (I) as heme oxygenase 1 (HMOX 1) inducers. The present invention is also related a method of controlling the activity or the amount, or both the activity and the amount, of heme-oxygenase 1 in a mammalian subject. The definitions of the variables are provided herein.
Benzoxazoles as Selective Monoamine Oxidase B (MAO-B) Inhibitors
Sawant, Vikram S.,Park, Hyeri,Baek, Soo Yoon,Lee, Jieon,Choi, Ji Won,Park, Ki Duk,Choi, Kyung Il,Seong, Jihye,Lee, Sanghee,Choo, Hyunah
, p. 457 - 460 (2019/04/03)
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Ortho-aminophenol derivative and preparation method thereof
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Paragraph 0080; 0087; 0088; 0088, (2018/07/15)
The invention first discloses a preparation method of an ortho-aminophenol derivative. The preparation method comprises the following steps: (1) by adopting an aryl amine compound as a substrate and 2-chloro-5-nitropyridine as a guiding base, reacting in acetonitrile, thus obtaining a pyridine aryl amine compound intermediate; (2) catalyzing the pyridine aryl amine compound intermediate in step (1) to make C-H activation reaction in a solvent by using iodobenzene diacetate as an oxidant and palladium acetate as a catalyst, thus obtaining an acetoxylation aniline derivative, draining, and thenperforming the chromatographic separation and purification; and (3) enabling the acetoxylation aniline derivative in step (2) to react in a tetrahydrofuran solvent for 30 min at a normal temperature by virtue of hydrazine hydrate, thus obtaining the ortho-aminophenol derivative, quenching, washing, extracting, drying, draining, and performing the chromatographic separation and purification. The invention also discloses the ortho-aminophenol derivative prepared by the method.