402-46-0

Basic information

• Product Name: 4-Fluorobenzenesulfonamide
• Synonyms: p-fluoro-benzenesulfonamid;p-fluorobenzenesulphonamide;Benzenesulfonamide, 4-fluoro- (9CI);p-Fluorobenzenesulfonamide (PFSA);4-Fluorobenzenesulphonamide97%;4-FLUROBENZENESULFONAMIDE;4-FLUOROBENZENESULFONAMIDE 97%;4-fluorobenzene-1-sulfonaMide
• CAS NO: 402-46-0
• Molecular Formula: C₆H₆FNO₂S
• Molecular Weight: 175.18
• EINECS: 206-946-2
• Product Categories: SULFONAMIDE;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds
• Mol File: 402-46-0.mol
• Article Data: 29

Chemical Properties

• Melting Point: 124-127 °C(lit.)
• Boiling Point: 307.9 °C at 760 mmHg
• Flash Point: 140 °C
• Appearance: /
• Density: 1.428 g/cm³
• Vapor Pressure: 0.000705mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.00±0.10(Predicted)
• Water Solubility: It is soluble in water.
• CAS DataBase Reference: 4-Fluorobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluorobenzenesulfonamide(402-46-0)
• EPA Substance Registry System: 4-Fluorobenzenesulfonamide(402-46-0)

Safety Data

• Hazard Codes: T,Xi
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-36-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: DB2630000
• HazardClass: IRRITANT
• Hazardous Substances Data: 402-46-0(Hazardous Substances Data)

Usage

Description

4-Fluorobenzenesulfonamide is a para-halogen benzenesulfonamide, which has been investigated using ab initio Hartree-Fock (HF) and density functional theory (DFT) to understand its structural features. It is a chemical compound with potential applications in various industries due to its unique properties.

Uses

Used in Pharmaceutical Industry:
4-Fluorobenzenesulfonamide is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. It plays a crucial role in the production of bis-(4-fluoro-benzenesulfonyl)-amine with 4-fluoro-benzenesulfonyl chloride at a temperature of 55 60 degrees Celsius. This reaction requires the reagent OH-, which is essential for the process.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-Fluorobenzenesulfonamide is utilized to synthesize 4-fluorophenylsulfonyldithiocarbimate potassium dihydrate and amino-substituted sulfanilamide derivatives. These synthesized compounds have potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Overall, 4-Fluorobenzenesulfonamide is a versatile compound with applications in the pharmaceutical industry and chemical synthesis. Its unique properties and ability to be used in the production of various compounds make it a valuable asset in the development of new products and technologies.

InChI:InChI=1/C6H6FNO2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,(H2,8,9,10)

Upstream product

• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 42467-05-0 4-substituted phenylthiol acetate 
• 138-41-0 4-(aminosulfonyl)-benzoic acid 
• 110-91-8 morpholine 
• 352-13-6 4-flourophenylmagnesium bromide 
• 371-40-4 4-fluoroaniline 
• 503596-47-2 N-sulfinyltriphenylmethylamine 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 2592-95-2 benzotriazol-1-ol 
• 371-42-6 4-Fluorothiophenol 
• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 349-89-3 p-chlorobenzenesulfonyl fluoride 
• 368-85-4 4-fluorobenzenesulfonyl fluoride 
• 462-06-6 fluorobenzene 

Downstream Products

• 1026364-78-2 N-(7-{3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-[3-(tert-butyl-dimethyl-silanyloxy)-4-phenylsulfanyl-butyl]-cyclopentyl}-heptanoyl)-benzenesulfonamide 
• 1026054-18-1 N-(7-{3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-[3-(tert-butyl-dimethyl-silanyloxy)-4-(2-fluoro-phenylsulfanyl)-butyl]-cyclopentyl}-heptanoyl)-4-fluoro-benzenesulfonamide 
• 406935-82-8 (E,E,E)-1,14-dibromo-N,N'-bis[(4-fluorophenyl)sulfonyl]-5,10-diazatetradeca-2,7,12-triene 
• 501682-71-9 N,N-bis[(E)-4-bromo-2-butenyl]-(4-fluorophenyl)-sulfonamide 
• 1006907-56-7 ethyl 1-[4-(aminosulfonyl)phenyl]-5-methyl-1H-pyrazole-3-carboxylate 
• 333997-35-6 4-(4-Benzyl-piperazin-1-yl)-benzenesulfonamide 
• 1263313-43-4 N-[2-(2,2-dimethyl-propionyl)-phenyl]-4-fluoro-benzenesulfonamide 
• 1360828-06-3 C₂₇H₂₁ClF₄N₆O₄S 

Relevant articles and documents

P2X7R ANTAGONISTS

A compound has Formula I: (I). R1 is hydrogen, hydroxy, halogen, nitro, amino, alkyl, alkoxy, alkylamino, cycloalkyl, cycloalkyamino, heterocyclyl, aryl, heteroaryl, -NR7R8, -CO-R10, or -NH-CO-R10; L is a bond, a heterocyclic bivalent group, a heteroaromatic bivalent group, or an aromatic bivalent group; M is a bond, alkyl, aryl, heterocyclic bivalent group, heteroaromatic bivalent group, or aromatic bivalent group; X is a bond, -O-, -S-, -SO2-, -CO-, -NR9-, -(CH2)m-, or heterocyclic bivalent group, m is 1, 2, 3, 4, 5, or 6; Y is a bond, -NH-, heterocyclic bivalent group, heteroaromatic bivalent group, bivalent benzyl group, or aromatic bivalent group; and Z is hydrogen, halogen, alkyl, aryl, heterocyclyl, heteroaryl, -NR7R8, -CO-R10, or -NH-CO-R10; R7, R8, and R9 are independently hydrogen, hydroxy, halogen, nitro, amino, alkyl, alkoxy, alkylamino, cycloalkyl, cycloalkyamino, heterocyclyl, or heteroaryl; and R10 is -O-tert-butyl, -CH2CH2-phenyl, hydrogen, hydroxy, halogen, nitro, amino, alkyl, alkoxy, alkylamino, cycloalkyl, cycloalkyamino, heterocyclyl, or heteroaryl.

Chromoselective Synthesis of Sulfonyl Chlorides and Sulfonamides with Potassium Poly(heptazine imide) Photocatalyst

Among external stimuli used to promote a chemical reaction, photocatalysis possesses a unique one—light. Photons are traceless reagents that provide an exclusive opportunity to alter chemoselectivity of the photocatalytic reaction varying the color of incident light. This strategy may be implemented by using a sensitizer capable to activate a specific reaction pathway depending on the excitation light. Herein, we use potassium poly(heptazine imide) (K-PHI), a type of carbon nitride, to generate selectively three different products from S-arylthioacetates simply varying the excitation light and otherwise identical conditions. Namely, arylchlorides are produced under UV/purple, sulfonyl chlorides with blue/white, and diaryldisulfides at green to red light. A combination of the negatively charged polyanion, highly positive potential of the valence band, presence of intraband states, ability to sensitize singlet oxygen, and multi-electron transfer is shown to enable this chromoselective conversion of thioacetates.

Nickel(II)-Catalyzed Addition of Aryl and Heteroaryl Boroxines to the Sulfinylamine Reagent TrNSO: The Catalytic Synthesis of Sulfinamides, Sulfonimidamides, and Primary Sulfonamides

We report a redox-neutral Ni(II)-catalyzed addition of (hetero)aryl boroxines to N-sulfinyltritylamine (TrNSO). The reactions use a catalyst generated from the combination of commercial, air-stable NiCl2·(glyme) and a commercially available bipyridine lig