4360-68-3Relevant articles and documents
Unravelling the allosteric targeting of phgdh at the act-binding domain with a photoactivatable diazirine probe and mass spectrometry experiments
Dochain, Simon,Feron, Olivier,Frédérick, Rapha?l,Ravez, Séverine,Spillier, Quentin,Thabault, Léopold,Vertommen, Didier
supporting information, (2021/06/28)
The serine biosynthetic pathway is a key element contributing to tumor proliferation. In recent years, targeting of phosphoglycerate dehydrogenase (PHGDH), the first enzyme of this pathway, intensified and revealed to be a promising strategy to develop ne
GEM-DISUBSTITUTED HETEROCYCLIC COMPOUNDS AND THEIR USE AS IDH INHIBITORS
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Page/Page column 63, (2021/05/15)
The present invention relates to certain gem-disubstituted heterocyclic compounds, which modulate the activity of Isocitrate Dehydrogenase (IDH). The compounds of this invention are therefore useful in treating diseases caused by mutated IDH1 and/or mutat
Tetrahedral Silicon-Centered Dibenzoylmethanatoboron Difluorides: Synthesis, Crystal Structure, and Photophysical Behavior in Solution and the Solid State
Kononevich, Yuriy N.,Temnikov, Maxim N.,Korlyukov, Alexander A.,Volodin, Alexander D.,Dorovatovskii, Pavel V.,Sazhnikov, Viacheslav A.,Safonov, Andrey A.,Ionov, Dmitriy S.,Ivanov, Anatoly A.,Surin, Nikolay M.,Svidchenko, Evgeniya A.,Muzafarov, Aziz M.
, p. 1111 - 1119 (2020/04/07)
Four tetrahedral silicon-centered derivatives of dibenzoylmethanatoboron difluoride (DBMBF2) were synthesized and characterized. Their structural and optical features both in solution and the solid state were investigated by using X-ray crystal