50972-17-3 Usage
Description
Bacampicillin, also known as Spectro Bac, is a semi-synthetic, microbiologically inactive prodrug of ampicillin. It is a penicillanic acid ester that is the 1-ethoxycarbonyloxyethyl ester of ampicillin. Bacampicillin is converted to ampicillin in the body, allowing for the effective treatment of various bacterial infections.
Uses
Used in Pharmaceutical Industry:
Bacampicillin is used as an antibiotic for the treatment of a wide range of bacterial infections, including respiratory tract infections, urinary tract infections, skin infections, and ear infections. It is effective against both gram-positive and gram-negative bacteria, such as Streptococcus pneumoniae, Haemophilus influenzae, and Escherichia coli.
Used in Medical Treatments:
Bacampicillin is used as a therapeutic agent for the management of bacterial infections in various medical conditions. It is particularly useful in treating infections that are resistant to other antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA).
Used in Veterinary Medicine:
Bacampicillin is also used in veterinary medicine for the treatment of bacterial infections in animals, such as dogs, cats, and livestock. It is effective in treating infections caused by various bacterial pathogens, including those that are resistant to other antibiotics.
Therapeutic Function
Antibacterial
Metabolism
Although comparatively well absorbed (30–55%), the oral efficacy of ampicillin for systemic infections can be
enhanced significantly through the preparation of pro-drugs. In contrast to ampicillin itself, which is
amphoteric, bacampicillin is a weak base and is very well absorbed in the duodenum (80–98%). Enzymatic
ester hydrolysis in the gut wall liberates carbon dioxide and ethanol, followed by spontaneous loss of
acetaldehyde and production of ampicillin. The acetaldehyde is metabolized oxidatively by alcohol
dehydrogenase to produce acetic acid, which joins the normal metabolic pool.
Check Digit Verification of cas no
The CAS Registry Mumber 50972-17-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,9,7 and 2 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 50972-17:
(7*5)+(6*0)+(5*9)+(4*7)+(3*2)+(2*1)+(1*7)=123
123 % 10 = 3
So 50972-17-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H27N3O7S/c1-5-29-20(28)31-11(2)30-19(27)15-21(3,4)32-18-14(17(26)24(15)18)23-16(25)13(22)12-9-7-6-8-10-12/h6-11,13-15,18H,5,22H2,1-4H3,(H,23,25)/t11?,13-,14-,15+,18-/m1/s1
50972-17-3Relevant articles and documents
Enhancement of the efficacy of nifedipine by deuteration
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, (2008/06/13)
A method of enhancing the efficiency and increasing the duration of action of drugs (e.g. dihydropyridines and anti-bacterials) and particularly of nifedipine and penicillins wherein one or more hydrogen atoms are deuterated and wherein the deuterated drug has unexpectedly improved properties when used in much lower concentrations than unmodified drug. A method for determining the identity and bioequivalency of a new drug is also disclosed wherein the molecular and isotope structure of a new drug is determined by isotope ratio mass spectrometry and compared with the molecular and isotope structure of a known human drug.
Pharmaceutical preparations containing α-aminopenicillins
-
, (2008/06/13)
New esters of α-aminopenicillins having the formula EQU1 wherein R is C2 -C7 alkyl; WHEREIN R2 = H or OH, R3 = H or halogen; SPC1 Wherein R1 is EQU2 or --Ch2 NHCOO--R4 wherein R4 = C1 -C4 alkyl; R5 = H, CH3 or C2 H5, useful as active ingredients of pharmaceutical preparation; processes for their preparation; chemical intermediates useful in said preparation; and methods for the treatment of infectious diseases.
