51344-14-0

Basic information

• Product Name: N,N-Dimethyl-2-(p-tolyloxy)ethanamine
• Synonyms: N,N-Dimethyl-2-(p-tolyloxy)ethanamine
• CAS NO: 51344-14-0
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.25878
• Mol File: 51344-14-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: N,N-Dimethyl-2-(p-tolyloxy)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Dimethyl-2-(p-tolyloxy)ethanamine(51344-14-0)
• EPA Substance Registry System: N,N-Dimethyl-2-(p-tolyloxy)ethanamine(51344-14-0)

Safety Data

• Hazardous Substances Data: 51344-14-0(Hazardous Substances Data)

Usage

General Description

N,N-Dimethyl-2-(p-tolyloxy)ethanamine, also known as DMBA, is a chemical compound that is commonly used as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals. It is a viscous, clear liquid with a strong amine odor. DMBA is an important building block in the synthesis of various pharmaceuticals, including anti-inflammatory drugs and antihistamines. It is also used in the production of pesticides and other agrochemicals. Additionally, DMBA has been studied for its potential use as a precursor in the development of new materials and polymers. However, it should be handled with caution due to its irritant and potentially harmful properties, and proper safety precautions should be taken when working with this chemical.

Upstream product

• 18800-34-5 1-bromo-2-(4'-methylphenoxy)ethane 
• 124-40-3 dimethyl amine 
• 106-44-5 p-cresol 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 624-31-7 4-tolyl iodide 
• 1121-70-6 sodium 4-methylphenoxide 
• 107-99-3 2-(dimethylamino)ethyl chloride 

Downstream Products

• 98766-39-3 (2-Chloro-benzyl)-dimethyl-(2-p-tolyloxy-ethyl)-ammonium; chloride 
• 2401-54-9 C₃₂H₅₄N₂O₂⁽²⁺⁾*2Br^(1-) 
• 106-44-5 p-cresol 
• 122892-31-3 N-<4-<2-(dimethylamino)ethoxy>benzyl>-3,4-dimethoxybenzamide hydrochloride 
• 122898-67-3 itopride 
• 98766-41-7 (4-Chloro-benzyl)-dimethyl-(2-p-tolyloxy-ethyl)-ammonium; chloride 
• 98766-29-1 Dimethyl-(4-nitro-benzyl)-(2-p-tolyloxy-ethyl)-ammonium; chloride 

Relevant articles and documents

Synthesis and characterization of herbicidal ionic liquids based on (4-chloro-2-methylphenoxy)acetate and phenoxyethylammonium

Ten ionic liquids containing the (4-chloro-2-methylphenoxy)acetate (MCPA) anion and domiphen derived phenoxyethylammonium cation were synthesized. The obtained compounds differed in terms of the substitution of the phenoxyethylammonium group in the ring (the presence of a methyl group in the meta or para positions and the presence of chlorine in the para position) as well as the length of the alkyl chain (from hexyl to tetradecyl). The basic physicochemical properties of the obtained ionic liquids (solubility and thermal stability) were characterized and their structures were confirmed. The herbicidal activity of the compounds was tested under greenhouse conditions using cornflower (Centaurea cyanus L.) as the test plant.

Preparation method of 4-(2-dimethylaminoethoxy)benzylamine

The invention provides a preparation method of 4-(2-dimethylaminoethoxy)benzylamine. The preparation method comprises the following steps: dissolving 4-(2-dimethylaminoethoxy)benzyl bromide and urotropin in a solvent and reacting; after reacting, recycling the solvent; hydrolyzing a reaction product under an acidic condition; and adding an alkali and neutralizing to obtain the 4-(2-dimethylaminoethoxy)benzylamine. According to the preparation method provided by the invention, the raw materials have low prices and are easy to obtain; industrialization of the process is easy to realize; and the final product has high purity.

Reaction of 1,2-difunctionalized ethanes with aryl iodides in copper-catalyzed cross-coupling: Application to synthesis of phenols

A series of 1,2-difunctionalized ethanes, such as ethylene glycol, 2-aminoethanol, 1,2-diaminoethane, 2-dimethylaminoethanol N',N'-dimethylethane-1,2-diamine, were investigated to test the reactivity with aryl iodides in the presence of copper catalysts. Under the reaction conditions, they produce the various Cheteroatom cross-coupled products. Interestingly, ethylene glycol and 2-dimethylaminoethanol afforded mainly the phenolic compounds while the others produced different cross-coupled products. Although ethylene glycol and 2-dimethylaminoethanol resulted in the same product, their behaviors in the reaction were quite different: ethylene glycol appears to mostly act as the ligand and 2-dimethylaminoethanol appears to serve as both the ligand and reactant. This finding led to a copper-catalyzed synthesis of phenols using either ethylene glycol or 2-dimethylaminoethanol, which can be applied to a variety of aryl iodides, providing an alternative synthetic route to phenols.