520-18-3Relevant articles and documents
Flavonoids as effective protectors of urease from ultrasonic inactivation in solutions
Tarun,Kurchenko,Metelitza
, p. 352 - 359 (2006)
Inactivation of soybean urease in aqueous solution at pH 5.4, 36°C, and high-frequency sonication (2.64 MHz, 1.0 W/cm2) is substantially reduced in the presence of seven structurally different flavonoids. A comparative kinetic study of the effect of these flavonoids on the effective first-order rate constants that characterize the total (thermal and ultrasonic) inactivation k i , thermal inactivation k*i, and ultrasonic inactivation k i (US) of 25 nM enzyme solution was carried out. The dependences of the three inactivation rate constants of the urease on the concentrations of flavonoids within the range from 10-11 to 10-4 M were obtained. The following order of the efficiency of the flavonoids used in respect of the urease protection from ultrasonic inactivation was found: astragalin > silybin > naringin > hesperidin > quercetin > kaempferol > morin. The results confirm a significant role in the inactivation of the urease of HO. and HO 2 . free radicals, which are formed in the ultrasonic cavitation field. Pleiades Publishing, Inc., 2006.
KAEMPFEROL DERIVATIVES FROM THE FRUIT OF THE JAPANESE PAGODA TREE
Akhmedkhodzhaeva, N. M.,Svechnikova, A. N.
, p. 116 - 117 (1983)
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Gumenyuk et al.
, (1971)
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Tannins, flavonol sulfonates, and a norlignan from Phyllanthus virgatus
Huang, Yu-Lin,Chen, Chien-Chih,Hsu, Feng-Lin,Chen, Chieh-Fu
, p. 1194 - 1197 (1998)
Investigation of the constituents of Phyllanthus virgatus has led to the isolation of five new compounds, including a norlignan, 2-(3,4- methylenedioxybenzyl)-4-(3,4-methylenedioxyphenyl)-3-butyne-1,2-diol named virgatyne (1); a hydrolyzable tannin, virganin (2); and three flavonoid sulfonates, galangin-8-sulfonate (4), galangin-3-O-β-D-glucoside-8- sulfonate (5), and kaempferol-8-sulfonate (6). Their structures were established by spectral and chemical methods.
FLAVONOIDS OF THE FLOWERS OF Cyclachaena xanthifolia
Kurkin, V. A.,Zapesochnaya, G. G.,Krivenchuk, P. E.,Yurkenik, A. Yu.,Artamonova, L. P.
, p. 366 - 367 (1984)
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A new acylated flavonol glycoside from the aerial parts of Cardamine tangutorum
Feng, Wei-Sheng,Zhang, Qiu-Bo,Zheng, Xiao-Ke,Chen, Hui,Zhang, Yan-Li,Zhang, Chun-Lei
, p. 805 - 810 (2012)
A new acylated flavonol glycoside, kaempferol-3-O-β-d-(2- feruloylglucopyranosyl) (1 → 6)-[β-d-glucopyranosyl(1 → 2)]-β-d-glucopyranoside, named tangutorumoside A (1), together with 12 known compounds, was isolated from 50% acetone extract of Cardamine tangutorum. Their structures were elucidated by NMR and MS experiments. In addition, compound 1 could promote the proliferation of splenic lymphocytes and thymic lymphocytes with ConA in vitro.
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Roshchin
, (1977)
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Samokish,Shinkurenko
, (1969)
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Anti-complement activity of tiliroside from the flower buds of Magnolia fargesii
Jung, Keun Young,Oh, Sei Ryang,Park, Si-Hyung,Lee, Im Seon,Ahn, Kyung Seop,Lee, Jung Joon,Lee, Hyeong-Kyu
, p. 1077 - 1078 (1998)
As part of the search for anticomplementary active components from natural products, the anticomplementary properties of methanolic extracts from the flower buds of Magnolia fargesii have been investigated. Bioassay- guided chromatographic Separation of the active constituents led to the isolation of compound 1, whose structure was identified by spectroscopic methods to be kaempferol 3-O-β-D-(6-O-coumaroyl)glucopyranoside (tiliroside). Tiliroside showed very potent anti-complement activity (IC50=5.4x 10-5 M) on the classical pathway of the complement system, even higher than rosmarinic acid, which is a well-known inhibitor against the complement system. On the other hand, the hydrolysates of tiliroside, kaempferol, astragalin and p-coumaric acid showed very weak activity on this system.
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Betkhi Tkhuan',Blinova
, (1974)
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Synthesis and Biological Evaluation of 4-Substituted Kaempfer-3-ols
Kim, Sugyeom,Lannigan, Deborah A.,Li, Yu,Lin, Lin,O'Doherty, George A.,Sayasith, Peyton R.,Tarr, Ariel T.,Wright, Eric B.,Yasmin, Sharia
, p. 4279 - 4288 (2020/04/09)
The synthesis of two series of five kaempfer-3-ols was described. The first set all have a C-3 hydroxyl group and the second has a carboxymethoxy ether at the C-3 position. Both series have variable substitution at the C-4 position (i.e., OH, Cl, F, H, OMe). Both kaempferols and carboxymethoxy ethers were evaluated for their ability to inhibit ribosomal s6 kinase (RSK) activity and cancer cell proliferation.
Preparation method of kaempferol
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Paragraph 0041-0042; 0051-0052; 0061-0062; 0063; 0071-0072, (2019/03/08)
The invention relates to a synthesis method of a bulk drug, in particular to a preparation method of kaempferol. The preparation method of the kaempferol is provided in order to solve the technical problems that in the prior art, when purified kaempferol is separated from plants, waste of plant resources and solvents is large, and a total-synthesis method of the kaempferol is long in synthesis route, many in step, low in yield, and difficult to meet the requirements of industrial production are difficult to meet. According to the preparation method, dihydromyricetin is selected as a starting raw material, a kaempferol crude product is obtained through three step reactions of hydrolysis, catalytic closed-loop and oxidation, and the kaempferol crude product is purified and refined to obtainkaempferol refined product with the qualified quality. According to the preparation method of the kaempferol, raw materials are easy to obtain, operation is easy, the cost is low, and the preparationmethod is suitable for industrial production.