56796-39-5 Usage
Description
Cefmetazole sodium is a semi-synthetic antibiotic derived from Cephamycin, characterized by its potent antibacterial properties.
Uses
Used in Pharmaceutical Industry:
Cefmetazole sodium is used as an antibiotic for the treatment of various bacterial infections. It is particularly effective against a wide range of gram-positive and some gram-negative bacteria, making it a valuable asset in combating resistant infections.
Used in Clinical Medicine:
Cefmetazole sodium is used in combination with Tanreqing for the treatment of pulmonary infections such as senile emphysema and other acute bacterial infections. Its synergistic action with Tanreqing enhances the therapeutic efficacy in managing these respiratory conditions.
Clinical Use
Cefmetazole (Zefazone) is a semisynthetic, third-generation,parenteral cephalosporin of the cephamycin group. Likeother cephamycins, the presence of the 7α-methoxyl groupconfers resistance to many β-lactamases. Cefmetazoleexhibits significantly higher potency against members ofthe Enterobacteriaceae family but lower activity againstBacteroides spp. than cefoxitin. It is highly active againstN. gonorrhoeae, including -lactamase–producing strains. Incommon with other cephamycins, cefmetazole is ineffectiveagainst indole-positive Proteus, Enterobacter, Providencia,Serratia, and Pseudomonas spp. Cefmetazole has the MTTmoiety associated with increased bleeding in certain highriskpatients. It has a plasma half-life of 1.1 hours.
Check Digit Verification of cas no
The CAS Registry Mumber 56796-39-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,7,9 and 6 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 56796-39:
(7*5)+(6*6)+(5*7)+(4*9)+(3*6)+(2*3)+(1*9)=175
175 % 10 = 5
So 56796-39-5 is a valid CAS Registry Number.
InChI:InChI=1/C15H17N7O5S3.Na/c1-21-14(18-19-20-21)30-6-8-5-29-13-15(27-2,17-9(23)7-28-4-3-16)12(26)22(13)10(8)11(24)25;/h13H,4-7H2,1-2H3,(H,17,23)(H,24,25);/q;+1/p-1/t13?,15-;/m0./s1
56796-39-5Relevant articles and documents
PROCESS FOR PREPARING CEFMETAZOLE SODIUM
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Paragraph 0034-0041, (2020/09/05)
The present invention relates to a method for manufacturing cefmetazole sodium. More specifically, the present invention relates to a method for manufacturing cefmetazole sodium by crystallization, wherein the method comprises the following steps: dissolving cefmetazole acid and sodium salt in an organic solvent; and then performing crystallization of a product after the reaction by using a crystallization solvent. Thus, the method can manufacture cefmetazole sodium without using lyophilization, which is an existing manufacturing method, while shortening the time and without additional equipment.COPYRIGHT KIPO 2020
A head spore US[...] synthesis and purification method
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Paragraph 0082; 0087-0090, (2017/02/02)
The invention discloses a cefmetazole sodium preparation method. The cefmetazole sodium preparation method comprises the following steps: preparing 7beta-chloroacetamide- 7alpha-methoxyl-3-(1-methyl-1H-tetrazole-5-mercaptomethy)-3-cephem-4-carboxylic acid through silanization, halogenation, methoxylation and secondary silanization of 7beta-dichloroacetamido-3-(1-methyl-1H-tetrazole-5-mercaptomethy)-3-cephem-4-carboxylic acid triethylamine salt serving as a starting material, and then carrying out chain extension and acid and salt formation, thus obtaining cefmetazole sodium. The cefmetazole sodium preparation method has the advantages that the yield is high and reaches 55-65%, the product is high in purity, the 7beta-dichloroacetamido-3-(1-methyl-1H-tetrazole-5-mercaptomethy)-3-cephem-4-carboxylic acid triethylamine salt is used for replacing 7-MAC and serves as the starting material, the raw material is convenient in source, low in cost and environmentally friendly, the product is high in purity and suitable for industrial production. and the like.
