579-13-5 Usage
Description
Oligomycin A, a macrolide antibiotic, is a dominant analog of macrocyclic lactones produced by Streptomyces species. It is characterized by its white powder form and exhibits a broad biological profile, including antifungal, antitumor, and nematocidal activities. However, its poor solubility in water and other biocompatible solvents limits its clinical application.
Uses
Used in Pharmaceutical Industry:
Oligomycin A is used as an antifungal agent for its fungicidal activity against various fungal pathogens. It is effective in treating fungal infections by inhibiting the mitochondrial F1F0-ATPase, which is essential for fungal cell energy production.
Used in Oncology:
Oligomycin A is used as an antitumor agent for its ability to induce apoptosis in a variety of cancer cell types. It makes cells more susceptible to cell death and can switch the death mode from apoptosis to necrosis, offering potential therapeutic benefits in cancer treatment.
Used in Nematode Control:
Oligomycin A is used as a nematocidal agent for its effectiveness against nematodes (roundworms). It can be employed in agricultural and veterinary applications to control nematode infestations and protect crops and animals from these parasites.
Used in Research and Development:
Oligomycin A is used as a research tool for studying mitochondrial function and apoptosis in various cell types. Its ability to inhibit mitochondrial F1F0-ATPase and induce cell death makes it a valuable compound for understanding cellular processes and developing new therapeutic strategies.
references
[1]. jastroch m, divakaruni as, mookerjee s, et al. mitochondrial proton and electron leaks. essays biochemistry, 2010, 47:53-67.[2]. shchepina la, pletjushkina oy, avetisyan av, et al. oligomycin, inhibitor of the f-0 part of h+-atp-synthase, suppresses the tnf-induced apoptosis. oncogene, 2002, 53: 8149-8157.[3]. salomon ar, voehringer dw, herzenberg la, et al. understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of f0f1-atpase. proceedings of the national academy of sciences of the united states of america, 2000, 97(26): 14766-14771.[4]. alexander r, adina v, ivan b, et al. overcoming intrinsic multi-drug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling jarid1bhigh cells. cancer cell, 2013, 23(6): 811-825.
Check Digit Verification of cas no
The CAS Registry Mumber 579-13-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,7 and 9 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 579-13:
(5*5)+(4*7)+(3*9)+(2*1)+(1*3)=85
85 % 10 = 5
So 579-13-5 is a valid CAS Registry Number.
InChI:InChI=1/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13-,17-15+,21-18+/t25-,26-,27+,28+,29+,30-,31-,32-,33-,34-,35-,36-,38+,40+,41+,42-,44+,45-/m1/s1
