5955-73-7

Basic information

• Product Name: 2-METHYLBENZOYL CYANIDE
• Synonyms: 2-METHYLBENZOYL CYANIDE;OXO-O-TOLYL-ACETONITRILE;2-methyl phenyl glyoxylonitrile;Benzeneacetonitrile, 2-Methyl-a-oxo-
• CAS NO: 5955-73-7
• Molecular Formula: C₉H₇NO
• Molecular Weight: 145.16
• EINECS: 200-258-5
• Mol File: 5955-73-7.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 239.226 °C at 760 mmHg
• Flash Point: 98.481 °C
• Appearance: /
• Density: 1.111 g/cm³
• Vapor Pressure: 0.041mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-METHYLBENZOYL CYANIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLBENZOYL CYANIDE(5955-73-7)
• EPA Substance Registry System: 2-METHYLBENZOYL CYANIDE(5955-73-7)

Safety Data

• Hazardous Substances Data: 5955-73-7(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C9H7NO/c1-7-4-2-3-5-8(7)9(11)6-10/h2-5H,1H3

Upstream product

• 592-04-1 mercury(II) cyanide 
• 933-88-0 ortho-toluoyl chloride 
• 84452-03-9 Dichloro-o-tolyl-acetonitrile 
• 22364-68-7 2-tolylmethylnitrile 
• 85589-34-0 2-hydroxy-2-(2-methylphenyl)acetonitrile 
• 74-90-8 hydrogen cyanide 
• 773837-37-9 sodium cyanide 
• 118-90-1 ortho-methylbenzoic acid 
• 143-33-9 sodium cyanide 
• 1052175-57-1 C₉H₈BrN 
• 529-20-4 2-methylphenyl aldehyde 
• 151-50-8 potassium cyanide 
• 82128-96-9 2-trimethylsilyloxy-2-(2-methylphenyl)acetonitrile 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 146439-70-5 3,4-dihydro-3-cyano-3-phenyl-1H-2-benzopyran-1-one 
• 2048-07-9 1,2-bis(2-methylphenyl)-1,2-ethanedione 
• 34966-54-6 methyl 2-oxo-2-(o-tolyl)acetate 
• 1255526-46-5 C₁₄H₁₁NO₃ 
• 1265379-64-3 C₁₇H₁₅NO₃ 
• 1255526-44-3 C₁₇H₁₅NO₃ 
• 133409-72-0 methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate 
• 89-71-4 2-Methyl-benzoic acid methyl ester 
• 66644-67-5 ethyl 2-methylbenzoylformate 
• 120974-97-2 methyl-(E)-2-(2-tolyl)-2-methoxyiminoacetate 
• 144106-03-6 (Z)-2-(2-tolyl)-2-methoxyiminoacetic acid methyl ester 

Relevant articles and documents

Preparation method of O-methylbenzoyl nitrile

The method comprises the following steps: firstly dissolving o-methylbenzoic acid in a toluene solvent, dropping the dimethyl sulfoxide to carry out reaction, and removing a small amount of unreacted dichlorosulphoxide at low temperature after the reactio

A stretching of the intermediate O-methyl benzoyl nitrile synthetic method

The invention relates to a method for preparing a key intermediate methylbenzoyl cyanide in the process of synthesizing trifloxystrobin. The method comprises the following steps: adding o-toluoyl chloride, a solvent and a catalyst into a reaction kettle; introducing metered hydrocyanic acid gas, completely reacting under a heat insulating conditon to obtain methylbenzoyl cyanide, and carrying out back-distillation to obtain a methylbenzoyl cyanide product. The content of methylbenzoyl cyanide is over 99 percent and the yield can be over 95 percent metered in form of o-toluoyl chloride. The method is simple and convenient to operate, the utilization of the raw material o-toluoyl chloride is high; except the byproduct hydrochloric acid, almost no other wastes are generated, and atomic economic reaction is basically realized. The method is a synthesizing process with good economic prospect.

Synthesis and biological evaluation of kresoxim-methyl analogues as novel inhibitors of hypoxia-inducible factor (HIF)-1 accumulation in cancer cells

We designed and synthesized strobilurin analogues as hypoxia-inducible factor (HIF) inhibitors based on the molecular structure of kresoxim-methyl. Biological evaluation in human colorectal cancer HCT116 cells showed that most of the synthesized kresoxim-methyl analogues possessed moderate to potent inhibitory activity against hypoxia-induced HIF-1 transcriptional activation. Three candidates, compounds 11b, 11c, and 11d were identified as potent inhibitors against HIF-1 activation with IC50 values of 0.60–0.94?μM. Under hypoxic condition, compounds 11b, 11c, and 11d increased the intracellular oxygen contents, thereby attenuating the hypoxia-induced accumulation of HIF-1α protein.